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T74270PROTAC BRD4 Degrader-17；化合物 PROTAC BRD4 Degrader-17PROTAC BRD4 Degrader-17
PROTAC BRD4 Degrader-17 (compound 13i), a potent inhibitor, exhibits IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)), effectively reducing Cyclin B1 expression linked with G2/M phase progression and significantly inducing apoptosis in MV-4-11 cells [1].
价 格：￥电议型 号：T74270产 地：中国大陆
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T74222ER degrader 3；化合物 ER degrader 3ER degrader 3
ER degrader 3, a potent estrogen receptor (ER) degrader, significantly impacts the estrogen signaling pathway, which is crucial for regulating cell growth, differentiation, and apoptosis. This compound holds potential for cancer research[1].
价 格：￥电议型 号：T74222产 地：中国大陆
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T74221ER degrader 2；化合物 ER degrader 2ER degrader 2
ER Degrader 2, a potent estrogen receptor (ER) degrader, plays a significant role in the estrogen signaling system, which is crucial for regulating cell growth, differentiation, and apoptosis. It holds promise for research in cancer diseases[1].
价 格：￥电议型 号：T74221产 地：中国大陆
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T74138PROTAC Bcl-xL degrader-2；化合物 PROTAC Bcl-xL degrader-2PROTAC Bcl-xL degrader-2
PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.
价 格：￥电议型 号：T74138产 地：中国大陆
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T74126PROTAC BRD4 Degrader-14；化合物 PROTAC BRD4 Degrader-14PROTAC BRD4 Degrader-14
PROTAC BRD4 Degrader-14, a PROTAC (Proteolysis Targeting Chimera) linked by ligands to von Hippel-Lindau and BRD4, exhibits IC50 values of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. This compound effectively degrades the BRD4 protein in PC3 prostate cancer cells [1].
价 格：￥电议型 号：T74126产 地：中国大陆
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T74125PROTAC BRD4 Degrader-12；化合物 PROTAC BRD4 Degrader-12PROTAC BRD4 Degrader-12
PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC that links von Hippel-Lindau and BRD4 ligands. When conjugated with STEAP1 and CLL1 antibodies, this compound effectively degrades BRD4 protein in PC3 prostate cancer cells, demonstrating potent activity with DC50 values of 0.39 nM and 0.24 nM, respectively [1].
价 格：￥电议型 号：T74125产 地：中国大陆
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T74124PROTAC BRD4 Degrader-11；化合物 PROTAC BRD4 Degrader-11PROTAC BRD4 Degrader-11
PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies. This compound exhibits potent activity, with degradation concentration half-maximal (DC50) values of 0.23 nM and 0.38 nM for the respective conjugations [1].
价 格：￥电议型 号：T74124产 地：中国大陆
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T74090PROTAC BRD4 Degrader-7；化合物 PROTAC BRD4 Degrader-7PROTAC BRD4 Degrader-7
PROTAC BRD4 Degrader-7, a potent bromodomain BRD4 inhibitor exemplified by compound 1a, demonstrates half-maximal inhibitory concentrations (IC50s) of 15.5 nM and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively [1].
价 格：￥电议型 号：T74090产 地：中国大陆
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T74062PROTAC IRAK4 degrader-2；化合物 PROTAC IRAK4 degrader-2PROTAC IRAK4 degrader-2
PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs). It also notably decreases IRAK4 protein levels with a DC50 of 36 nM in the same cell type and inhibits several cytokines in PBMCs [1].
价 格：￥电议型 号：T74062产 地：中国大陆
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T73999PROTAC Bcl-xL degrader-3；化合物 PROTAC Bcl-xL degrader-3PROTAC Bcl-xL degrader-3
PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.
价 格：￥电议型 号：T73999产 地：中国大陆
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T73958PROTAC BRD4 Degrader-6；化合物 PROTAC BRD4 Degrader-6PROTAC BRD4 Degrader-6
PROTAC BRD4 Degrader-6 (compound 32a), a potent small-molecule degrader of BRD4, exhibits an IC50 of 2.7 nM for BRD4 BD1. It effectively degrades BRD4 protein, suppresses c-Myc expression, and inhibits the proliferation of the pancreatic cancer cell line BxPC3 by inducing apoptosis. This compound is applicable in research on human pancreatic cancer [1].
价 格：￥电议型 号：T73958产 地：中国大陆
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T73957PROTAC Bcl-xL degrader-1；化合物 PROTAC Bcl-xL degrader-1PROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 is a potent PROTAC composed of a Bcl-xL (Bcl-2 family member) ligand-binding group, a linker, and an IAP E3 ligases binding group, demonstrating effectiveness as a Bcl-xL degrader. It exhibits toxicity towards human platelets and MyLa 1929 cells, with IC50 values of 62 nM and 8.5 μM, respectively [1].
价 格：￥电议型 号：T73957产 地：中国大陆
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T73868PROTAC BTK Degrader-2；化合物 PROTAC BTK Degrader-2PROTAC BTK Degrader-2
PROTAC BTK Degrader-2, a potent degrader of BTK through the PROTAC mechanism, effectively diminishes BTK protein levels [1].
价 格：￥电议型 号：T73868产 地：中国大陆
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T73835PROTAC HSP90 degrader BP3；化合物 PROTAC HSP90 degrader BP3PROTAC HSP90 degrader BP3
PROTAC HSP90 degrader BP3 potently and selectively degrades HSP90 through a CRBN-dependent mechanism. It effectively diminishes HSP90 protein levels in MCF-7 cells with a half-maximal degradation concentration (DC50) of 0.99 ?M. Additionally, this compound impedes the proliferation of breast cancer cells [1].
价 格：￥电议型 号：T73835产 地：中国大陆
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T73726PROTAC AR Degrader-4 TFA；化合物 PROTAC AR Degrader-4 TFAPROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4, an Androgen Receptor (AR) degrader, incorporates an IAP ligand binding group, a linker, and an AR binding group. It represents a class of degradation inducers known as specific and non-genetic IAP-dependent protein erasers (SNIPERs) [1], operating through a mechanism involving cIAP1.
价 格：￥电议型 号：T73726产 地：中国大陆
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T72291Mitochondria degrader-1；化合物 Mitochondria degrader-1Mitochondria degrader-1
Mitochondria Degrader-1 (example 5) is a potent agent for inducing the autophagic degradation of damaged mitochondria. It is applicable in the research of various conditions including neurodegenerative, cancer, inflammatory, age-related, metabolic, mitochondrial, and Down´s diseases.
价 格：￥电议型 号：T72291产 地：中国大陆
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T69753HDAC6 degrader 9c；HDAC6 降解剂9cHDAC6 degrader 9c
HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.
价 格：￥电议型 号：T69753产 地：中国大陆
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T69525MIF degrader MD13；化合物 MIF degrader MD13MIF degrader MD13
MIF degrader MD13 is involved in protein-protein interactions that play key roles in inflammation and cancer. Current strategies to develop small molecule modulators of MIF functions are mainly restricted to the MIF tautomerase active siteMIF degrader MD13. MD13 also exhibits antiproliferative effect in a 3D tumor spheroid model. In conclusion, we describe the first MIF-directed PROTAC (MD13) as a research tool, which also demonstrates the potential of PROTACs in cancer therapy.
价 格：￥电议型 号：T69525产 地：中国大陆
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T64284PROTAC CDK12/13 Degrader-1；化合物 PROTAC CDK12/13 Degrader-1PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) is a potent and selective dual degrader of the cell cycle protein-dependent kinases CDK12 (DC50: 2.2 nM) and CDK13 (DC50: 2.1 nM). Breast cancer.
价 格：￥电议型 号：T64284产 地：中国大陆
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T64161XIAP degrader-1；化合物 XIAP degrader-1XIAP degrader-1
XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).
价 格：￥电议型 号：T64161产 地：中国大陆
