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T40294ITK/TRKA-IN-1;ITK/TRKA-IN-1ITK/TRKA-IN-1
ITK/TRKA-IN-1 is a chemical compound that functions as a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA). With an IC50 value of 1.0 nM, it effectively inhibits the activity of ITK, while demonstrating a remarkable 96% inhibition of TRKA.
价 格:¥电议型 号:T40294产 地:中国大陆
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T40278PDE2A-IN-1PDE2A-IN-1PDE2A-IN-1
PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC 50 value of 1.3 nM.
价 格:¥电议型 号:T40278产 地:中国大陆
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T40275DHPS-IN-1;DHPS-IN-1DHPS-IN-1
DHPS-IN-1, a chemical compound, demonstrates exceptional inhibitory potency against melanoma cells, as evidenced by its IC50 value of 0.014 μM.
价 格:¥电议型 号:T40275产 地:中国大陆
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T40263CDK5-IN-1CDK5-IN-1CDK5-IN-1
CDK5-IN-1 is a highly potent inhibitor of CDK5, displaying an inhibitory activity of less than 10 nM. This potent compound is specifically employed in scientific investigations relating to kidney diseases.
价 格:¥电议型 号:T40263产 地:中国大陆
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T40243αvβ5 integrin-IN-1;αvβ5 integrin-IN-1αvβ5 integrin-IN-1
αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.
价 格:¥电议型 号:T40243产 地:中国大陆
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T40242DEPTOR-IN-1;化合物DEPTOR-IN-1DEPTOR-IN-1
DEPTOR-IN-1 is an inhibitor of DEPTOR with a Kd of 9.3 μM.
价 格:¥电议型 号:T40242产 地:中国大陆
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T40237Carboxylesterase-IN-1;Carboxylesterase-IN-1Carboxylesterase-IN-1
Carboxylesterase-IN-1, a novel pesticide, acts as an inhibitor of carboxylesterase at a concentration of 50 μg/mL, displaying comparable inhibitory activity to the established inhibitor triphenyl phosphate.
价 格:¥电议型 号:T40237产 地:中国大陆
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T40232KIF18A-IN-1;KIF18A-IN-1KIF18A-IN-1;KIF18A-IN-1
KIF18A-IN-1 is a potent inhibitor of the mitotic kinesin KIF18A. This compound demonstrates significant anti-tumor properties.
价 格:¥电议型 号:T40232产 地:中国大陆
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T40218BCAT-IN-1BCAT-IN-1BCAT IN 1|||BCATIN1
BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC 50 of 7.3. BCAT-IN-1 is 100-fold more selective for BCATm than BCATc ( pIC 50 =5.4). BCAT-IN-1 can be used for the research of metabolic diseases [1].
价 格:¥电议型 号:T40218产 地:中国大陆
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T40216PTPN22-IN-1;PTPN22-IN-1PTPN22-IN-1;PTPN22-IN-1
PTPN22-IN-1, detailed in WO2021007491A1 as compound L-1, is a potent PTPN22 inhibitor, demonstrating an IC50 of 1.4 μM and a Ki of 0.50 μM. This compound achieves over 7-10 fold selectivity against PTPN22 relative to comparable phosphatases and enhances antitumor immune responses.
价 格:¥电议型 号:T40216产 地:中国大陆
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T40211eIF4E-IN-1eIF4E-IN-1eIF4E-IN-1
eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1 functions to disrupt immune suppression and promote immune release in specific diseases such as cancer and infectious diseases.
价 格:¥电议型 号:T40211产 地:中国大陆
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T40209EGFR-IN-15;EGFR-IN-15EGFR-IN-15
EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications.
价 格:¥电议型 号:T40209产 地:中国大陆
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T40202PRMT5-IN-12PRMT5-IN-12PRMT5-IN-12
PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .
价 格:¥电议型 号:T40202产 地:中国大陆
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T40197PRMT5-IN-11;PRMT5-IN-11PRMT5-IN-11;PRMT5-IN-11
PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.
价 格:¥电议型 号:T40197产 地:中国大陆
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T40183FAK-IN-1;FAK-IN-1FAK-IN-1
FAK-IN-1 is a FAK inhibitor with anticancer activities (WO2020231726 (Example 27)).
价 格:¥电议型 号:T40183产 地:中国大陆
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T40168DHODH-IN-16;化合物DHODH-IN-16DHODH-IN-16
DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).
价 格:¥电议型 号:T40168产 地:中国大陆
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T40146Sec61-IN-1;化合物Sec61-IN-1Sec61-IN-1;Sec61-IN-1
Sec61-IN-1 is a potent sec61 inhibitor.
价 格:¥电议型 号:T40146产 地:中国大陆
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T40137MPO-IN-1;MPO-IN-1MPO-IN-1
MPO-IN-1 is a powerful and orally bioavailable indole-containing inhibitor that acts irrevocably on myeloperoxidase (MPO). With IC50 values of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively, MPO-IN-1 effectively inhibits both enzymes. Furthermore, it exhibits remarkable MPO inhibitory activity in an acute inflammation mouse model.
价 格:¥电议型 号:T40137产 地:中国大陆
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T40109APOL1-IN-1;APOL1抑制剂1APOL1-IN-1;APOL1-IN-1
APOL1-IN-1 is a potent inhibitor of apolipoprotein L1 (APOL1) that can be used to study the pathogenesis of focal segmental glomerulosclerosis (FSGS) and nondiabetic kidney disease (NDKD), facilitating research into these diseases.
价 格:¥电议型 号:T40109产 地:中国大陆
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T40093IDO-IN-15;IDO-IN-15IDO-IN-15
IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).
价 格:¥电议型 号:T40093产 地:中国大陆