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T23522W-13 hydrochloride;化合物W-13盐酸盐W-13 HCl;W-13 HCl
W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.
价 格:¥电议型 号:T23522产 地:中国大陆
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T23512VU 0364739 hydrochloride;VU 0364739 盐酸盐VU 0364739 HCl;VU 0364739 HCl
VU 0364739 hydrochloride (VU 0364739 HCl) is a selective and potent inhibitor of phospholipase D2 (PLD2) with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively.VU 0364739 hydrochloride exhibits potential anticancer activity and induces apoptosis. VU 0364739 hydrochloride has potential anticancer activity, induces apoptosis, and can be used in the study of cancer and metabolic-related diseases.
价 格:¥电议型 号:T23512产 地:中国大陆
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T23451Tedizolid HCl (856866-72-3 free base);化合物 T23451Tedizolid HCl;Tedizolid HCl
Tedizolid HCl is a reversible, novel oxazolidinone antibiotic (IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM). It is the first oxazolidinone to be approved since linezolid in 2000. Tedizolid phosphate is the second commercially available oxazolidinone antibiotic and is the prodrug form of tedizolid with a fixed once-daily dose. As an expanded-spectrum oxazolidinone, it has potent activity against a wide range of Gram-positive pathogens.
价 格:¥电议型 号:T23451产 地:中国大陆
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T23418Tandutinib (MLN518) HCl;化合物 T23418Tandutinib (MLN518) HCl
Tandutinib is an effective antagonist for FLT3, platelet-derived growth factor receptor (PDGFR), and c-Kit. Tandutinib potently inhibited the activity of FLT3, PDGFR, and c-Kit (IC50: ~200 nM).
价 格:¥电议型 号:T23418产 地:中国大陆
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T23337SCH772984 HCl;化合物SCH772984 HClSCH772984 HCl
SCH772984 HCl is a selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors, with IC50s of 4 and 1 nM, respectively. SCH772984 HCl has nanomolar cellular potency in tumor cells with mutations in BRAF, NRAS, or KRA
价 格:¥电议型 号:T23337产 地:中国大陆
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T2330LRilpivirine HCl化合物 T2330LRilpivirine hydrochloride|||TMC278|||Rilpivirine|||TMC-278|||TMC 278. trade
Rilpivirine is a potent non-nucleoside reverse transcriptase inhibitor.
价 格:¥电议型 号:T2330L产 地:中国大陆
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T23288L(S)-3,4-DCPG HCl;(S)-3,4-DCPG 盐酸盐(S)-3,4-Dicarboxyphenylglycine HCl|||(S)-3,4-DCPG HCl(201730-11-2 F
(S)-3,4-DCPG HCl ((S)-3,4-Dicarboxyphenylglycine HCl) is a selective metabotropic glutamate receptor 8a (mGluR8a) agonist that has an effect on human mGluR8-expressing AV12-664 cells with an EC50 of 31 nM.
价 格:¥电议型 号:T23288L产 地:中国大陆
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T23265RS 67333 hydrochloride;盐酸RS67333RS 67333 (hydrochloride)|||RS 67333 HCl;RS 67333 (hydrochloride)|||R
RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer´s disease research.
价 格:¥电议型 号:T23265产 地:中国大陆
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T23227(R,R)-THC化合物 T23227(R,R)THC|||(R,R) THC
agonist at ERα receptor and antagonist at ERβ receptor
价 格:¥电议型 号:T23227产 地:中国大陆
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T23215L(R)-3,4-DCPG HCl;(R)-3,4-DCPG 盐酸盐(R)-3,4-DCPG HCl(201730-10-1 Free base);(R)-3,4-DCPG HCl(201730-10-
(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
价 格:¥电议型 号:T23215L产 地:中国大陆
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T2319Acotiamide monohydrochloride trihydrate盐酸阿考替胺Acotiamide hydrochloride|||YM-443 HCl|||盐酸阿考替胺|||Z-338
Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to
价 格:¥电议型 号:T2319产 地:中国大陆
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T2315GSK-LSD1 dihydrochloride;化合物GSK-LSD1 dihydrochlorideGSK-LSD1 (hydrochloride)|||GSK-LSD1 2HCl;GSK-LSD
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).
价 格:¥电议型 号:T2315产 地:中国大陆
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T23149Phenyl-benzothiazole HCl (92-36-4 free base);化合物 T23149Phenyl-benzothiazole HCl;Phenyl-benzothiazole
An azole for proteomics research
价 格:¥电议型 号:T23149产 地:中国大陆
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T23143PG 01037 dihydrochloride;PG01037盐酸盐PG-01037 2HCl;PG-01037 2HCl
PG 01037 dihydrochloride (PG-01037 2HCl) is a potent and selective dopamine D3 receptor antagonist with a Ki of 0.7 nM.
价 格:¥电议型 号:T23143产 地:中国大陆
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T2310LCHIR-99021 HCl;CHIR-99021盐酸盐CT99021 HCl|||Laduviglusib HCl;CT99021 HCl|||Laduviglusib HCl
CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivity over CDC2, ERK2, and other protein kinases. Additionally, CHIR-99021 HCl serves as a robust activator of the Wnt/β-catenin signaling pathway. Moreover, it exhibits the ability to enhance self-renewal in both mouse and human embryonic stem cells. Furthermore, CHIR-99021 HCl indu
价 格:¥电议型 号:T2310L产 地:中国大陆
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T2304SP2509;化合物SP2509HCI-2509;HCI-2509
SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM).
价 格:¥电议型 号:T2304产 地:中国大陆
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T23028MRT67307 HCl (1190378-57-4 free base);化合物 T23028MRT67307 HCl;MRT67307 HCl
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.
SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth价 格:¥电议型 号:T23028产 地:中国大陆
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T22957LY2606368 HCl (1234015-52-1 free base);化合物 T22957LY2606368 HCl;LY2606368 HCl
LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1 (IC50: 1.5nM in SW1990 cells).
价 格:¥电议型 号:T22957产 地:中国大陆
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T22936Idalopirdine Hydrochloride;Lu AE58054盐酸盐Lu AE58054 Hydrochloride|||Idalopirdine HCl;Lu AE58054盐酸盐|||
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.83 nM).
价 格:¥电议型 号:T22936产 地:中国大陆
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T2287PIK-75 hydrochloride化合物PIK-75 hydrochloridePIK-75 HCl|||2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.
价 格:¥电议型 号:T2287产 地:中国大陆