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T68459RO4927350;化合物 RO4927350RO4927350
RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a broad spectrum of tumor models. RO4927350 inhibits not only ERK1/2 but also MEK1/2 phosphorylation. In cancer cells, high basal levels of phospho-MEK1/2 rather than phospho-ERK1/2 seem to correlate with greater sensitivity to RO4927350. Furthermore, RO4927350 prevents a feedback inc
价 格:¥电议型 号:T68459产 地:中国大陆
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T68458Fostriecin (free base);化合物 Fostriecin (free base)Fostriecin (free base)
Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antib
价 格:¥电议型 号:T68458产 地:中国大陆
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T68457GSK812397;化合物 GSK812397GSK812397
GSK812397 is a potent entry inhibitor of X4-tropic strains of HIV-1, as demonstrated in multiple in vitro cellular assays. GSK812397 is a noncompetitive antagonist of the CXCR4 receptor, with GSK812397 producing a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50s were 0.34+/-0.01 nM and 2.41+/-0.50 nM, respectively). GSK812397 is effective against a broad range of X4- and X4R5-utilizing clinical isolates. The potency and efficacy of GS
价 格:¥电议型 号:T68457产 地:中国大陆
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T68456Dexlofexidine HCl;化合物 Dexlofexidine HClDexlofexidine HCl
Dexlofexidine HCl is the salt form of Dexlofexidine Free Base, an isomer “+“ of lofexidine, which is an agonist of alpha 2-adrenoceptor, but in 10 times less potent than the other isomer, levlofexidine
价 格:¥电议型 号:T68456产 地:中国大陆
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T68455AP23846;化合物 AP23846AP-23846;AP-23846
AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream angiogenic processes in human solid tumor cell lines.
价 格:¥电议型 号:T68455产 地:中国大陆
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T68454IAV inhibitor 4l;化合物 IAV inhibitor 4lIAV inhibitor 4l
IAV inhibitor 4l is an IAV inhibitor targeting hemagglutinin and mediates viral entry by preventing HA-membrane fusion.
价 格:¥电议型 号:T68454产 地:中国大陆
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T68452H 142-08;化合物 H 142-08H 142-08
H 142-08 is a partial beta 1-agonist with adrenoreceptor stimulatory effects.
价 格:¥电议型 号:T68452产 地:中国大陆
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T68451AG-28262 besylate;化合物 AG-28262 besylateAG-28262 besylate
AG-28262 besylate is a VEGFR-2 Inhibitorwhich may affect alanine aminotransferase gene expression and enzymatic activity in the liver.
价 格:¥电议型 号:T68451产 地:中国大陆
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T68450IDX-989;化合物 IDX-989IDX-989
IDX-989 is an HIV-1 non-nucleoside reverse transcriptase inhibitor.
价 格:¥电议型 号:T68450产 地:中国大陆
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T6845GNE-317;化合物GNE317GNE317;GNE317
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
价 格:¥电议型 号:T6845产 地:中国大陆
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T68449JFD00950;化合物 JFD00950JFD00950
JFD00950 is a human flap endonuclease 1 (FEN1) inhibitor with in vitro inhibition of flap cleavage activity as well as cytotoxic activity against a colon cancer cell line, DLD-1.
价 格:¥电议型 号:T68449产 地:中国大陆
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T68448XAX-162;化合物 XAX-162XAX-162
XAX-162 is an agonist of Sphingosine 1-phosphate receptor 2 (S1PR2)
价 格:¥电议型 号:T68448产 地:中国大陆
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T68447BM-42304;化合物 BM-42304BM-42304
BM-42304 is an inhibitor of fatty acid oxidation.
价 格:¥电议型 号:T68447产 地:中国大陆
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T68446AG-17724;化合物 AG-17724AG-17724
AG-17724 is a potent peptidyl-prolyl isomerase (PPIase) Pin1 inhibitor.
价 格:¥电议型 号:T68446产 地:中国大陆
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T68445Clomoxir;化合物 ClomoxirClomoxir
Clomoxir is a carnitine palmitoyltransferase I inhibitor that was under development as an antiarrhythmic and antidiabetic.
价 格:¥电议型 号:T68445产 地:中国大陆
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T68444Dircin;化合物 DircinDircin
Dircin is an anti-inflammatory agent, prescribed for osteoarthritis and chronic inflammatory arthritis. It works by inhibiting interleukin-1.
价 格:¥电议型 号:T68444产 地:中国大陆
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T68443PI-540;化合物 PI-540PI-540
PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).
价 格:¥电议型 号:T68443产 地:中国大陆
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T68442Desacetylravidomycin;化合物 DesacetylravidomycinDesacetylravidomycin
Desacetylravidomycin is a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp. WK-6326.
价 格:¥电议型 号:T68442产 地:中国大陆
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T68441SABRAC;化合物 SABRACSABRAC
SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = <1 ?M), as well as induces accumulation of ceramides in the same cells.
价 格:¥电议型 号:T68441产 地:中国大陆