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T75030Ubiquitination-IN-2；化合物 Ubiquitination-IN-2Ubiquitination-IN-2
Ubiquitination-IN-2 is a potent inhibitor of E1-E2 protein?protein interactions (PPI), displaying inhibitory activity with a dissociation constant (Kd) of 0.72 μM for the ubiquitin E1 (Uba1) enzyme. By blocking the transfer of ubiquitin from E1 to E2, Ubiquitination-IN-2 serves as a valuable tool in cancer research [1].
价 格：￥电议型 号：T75030产 地：中国大陆
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T7503Upadacitinib；乌帕替尼ABT-494；乌帕替尼|||ABT-494
Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.
价 格：￥电议型 号：T7503产 地：中国大陆
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T7502LPF 05089771；化合物PF-05089771PF-05089771|||PF05089771；PF-05089771|||PF05089771
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.
价 格：￥电议型 号：T7502L产 地：中国大陆
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T75029HEMTAC CDK4/6 degrader 1；化合物 HEMTAC CDK4/6 degrader 1HEMTAC CDK4/6 degrader 1
HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a K d value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests cell cycle at G0/G1 phase and induces apoptosis . HEMTAC CDK4/6 degrader 1 can be used in research of cancer [1] .
价 格：￥电议型 号：T75029产 地：中国大陆
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T75028TMV-IN-4；化合物 TMV-IN-4TMV-IN-4
TMV-IN-4 (Compound 3), a tobacco mosaic virus (TMV) inhibitor, effectively strengthens plant resistance and tolerance to TMV by binding with the TMV helicase. Furthermore, it boosts activities of peroxidase and superoxide dismutase, augmenting tobacco´s resilience to TMV infection [1].
价 格：￥电议型 号：T75028产 地：中国大陆
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T75027G0-C14；化合物 G0-C14G0-C14
G0-C14, an alkyl-modified polyamidoamine (PAMAM) dendrimer with cationic lipid-like properties, is utilized in the development of macrophage-targeted nanoparticles (NPs) for agent and vaccine delivery [1] [2].
价 格：￥电议型 号：T75027产 地：中国大陆
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T75026PROTAC TYK2 degradation agent1；化合物 PROTAC TYK2 degradation agent1PROTAC TYK2 degradation agent1
PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmune disease research [1].
价 格：￥电议型 号：T75026产 地：中国大陆
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T75025ChoKα inhibitor-5；化合物 ChoKα inhibitor-5ChoKα inhibitor-5
ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis. It is utilized in cancer research [1].
价 格：￥电议型 号：T75025产 地：中国大陆
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T75024ChoKα inhibitor-3；化合物 ChoKα inhibitor-3ChoKα inhibitor-3
ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability to induce apoptosis. This compound is utilized in cancer research [1].
价 格：￥电议型 号：T75024产 地：中国大陆
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T75023Nampt degrader-2；化合物 Nampt degrader-2Nampt degrader-2
Nampt degrader-2, a fluorescent PROTAC, exhibits efficient degradation of NAMPT at an IC50 of 41.9 nM. It operates by binding to both NAMPT and VHL, initiating the formation of a ternary complex that triggers NAMPT degradation through the ubiquitin-proteasome system (UPS). This activity significantly lowers NAD+ levels and displays potent antitumor effects [1].
价 格：￥电议型 号：T75023产 地：中国大陆
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T75022JZP-MA-11；化合物 JZP-MA-11JZP-MA-11
JZP-MA-11 is a positron emission tomography (PET) ligand that specifically targets the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. It exhibits selective inhibition of ABHD6, achieving an IC50 value of 126 nM and is capable of crossing the blood-brain barrier (BBB). The compound, labeled with [18F], demonstrates promising potential for preclinical evaluation in both mice and nonhuman primates (NHP) as a tool for investigating brain ABHD6 activity [1].
价 格：￥电议型 号：T75022产 地：中国大陆
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T75021SZUH280；化合物 SZUH280SZUH280
SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells. It induces apoptosis in cancer cells and impedes DNA damage repair, thereby enhancing cellular radiosensitization [1].
价 格：￥电议型 号：T75021产 地：中国大陆
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T75020PROTAC SOS1 degrader-3；化合物 PROTAC SOS1 degrader-3PROTAC SOS1 degrader-3
PROTAC SOS1 Degrader-3 is a potent agent specifically designed to target and degrade SOS1 via the ubiquitin-proteasome system [1].
价 格：￥电议型 号：T75020产 地：中国大陆
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T7502PF 05089771 tosylate；化合物PF 05089771 tosylatePF 05089771 tosylate
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50: 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50: ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50: 10/20 μM). PF-05089771 is also 1, 000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation o
价 格：￥电议型 号：T7502产 地：中国大陆
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T75019Antituberculosis agent-7；化合物 Antituberculosis agent-7Antituberculosis agent-7
Antituberculosis agent-7, an oxetanyl-quinoline derivative, exhibits potent antibacterial activity against P. mirabilis, with a minimum inhibitory concentration (MIC) of 31.25 μM, and antifungal efficacy against A. niger, with a MIC of 62.5 μM. Furthermore, it demonstrates remarkable antimycobacterial activity, achieving a MIC of 3.41 μM against M. tuberculosis H37Rv [1].
价 格：￥电议型 号：T75019产 地：中国大陆
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T75017PROTAC HDAC6 degrader 1；化合物 PROTAC HDAC6 degrader 1PROTAC HDAC6 degrader 1
Compound A6, a potent and selective PROTAC HDAC6 degrader, exhibits a DC50 of 3.5 nM. It demonstrates notable antiproliferative activity by inducing apoptosis in myeloid leukemia cell lines [1].
价 格：￥电议型 号：T75017产 地：中国大陆
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T75016Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal；化合物 Glucocorticoid receptor agonist-1 phosph
Glucocorticoid Receptor Agonist-1 Phosphate Ala-Ala-Mal functions as a glucocorticoid receptor agonist, utilized in the formulation of anti-CD40 antibody agent conjugates (ADC). It serves as a research tool for exploring inflammation and immune regulation [1].
价 格：￥电议型 号：T75016产 地：中国大陆
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T75015HX103；化合物 HX103HX103
HX103, an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-based fluorogenic probe, exhibits selective inhibition towards various EGFR mutations, including EGFR 19 del, EGFR L858R, EGFR wild type, and EGFR T790M, with respective IC50 values of 1.3, 1.5, 4.0, and 977 nM. It is utilized for quantifying active-EGFR to foresee agent sensitivity in NSCLC (non-small cell lung cancer) patients harboring EGFR-activating mutations [1].
价 格：￥电议型 号：T75015产 地：中国大陆
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T75014Antiproliferative agent-18；化合物 Antiproliferative agent-18Antiproliferative agent-18
Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1].
价 格：￥电议型 号：T75014产 地：中国大陆
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T75013SB26019；化合物 SB26019SB26019
SB26019 is a potent anti-neuroinflammatory compound that modulates the activation of NF-κB by promoting the formation of monomeric α-tubulin. This action of SB26019, in turn, hinders the translocation of p65, signifying its regulatory effect on neuroinflammatory processes [1].
价 格：￥电议型 号：T75013产 地：中国大陆
