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T74090PROTAC BRD4 Degrader-7；化合物 PROTAC BRD4 Degrader-7PROTAC BRD4 Degrader-7
PROTAC BRD4 Degrader-7, a potent bromodomain BRD4 inhibitor exemplified by compound 1a, demonstrates half-maximal inhibitory concentrations (IC50s) of 15.5 nM and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively [1].
价 格：￥电议型 号：T74090产 地：中国大陆
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T74062PROTAC IRAK4 degrader-2；化合物 PROTAC IRAK4 degrader-2PROTAC IRAK4 degrader-2
PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs). It also notably decreases IRAK4 protein levels with a DC50 of 36 nM in the same cell type and inhibits several cytokines in PBMCs [1].
价 格：￥电议型 号：T74062产 地：中国大陆
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T73999PROTAC Bcl-xL degrader-3；化合物 PROTAC Bcl-xL degrader-3PROTAC Bcl-xL degrader-3
PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.
价 格：￥电议型 号：T73999产 地：中国大陆
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T73958PROTAC BRD4 Degrader-6；化合物 PROTAC BRD4 Degrader-6PROTAC BRD4 Degrader-6
PROTAC BRD4 Degrader-6 (compound 32a), a potent small-molecule degrader of BRD4, exhibits an IC50 of 2.7 nM for BRD4 BD1. It effectively degrades BRD4 protein, suppresses c-Myc expression, and inhibits the proliferation of the pancreatic cancer cell line BxPC3 by inducing apoptosis. This compound is applicable in research on human pancreatic cancer [1].
价 格：￥电议型 号：T73958产 地：中国大陆
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T73957PROTAC Bcl-xL degrader-1；化合物 PROTAC Bcl-xL degrader-1PROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 is a potent PROTAC composed of a Bcl-xL (Bcl-2 family member) ligand-binding group, a linker, and an IAP E3 ligases binding group, demonstrating effectiveness as a Bcl-xL degrader. It exhibits toxicity towards human platelets and MyLa 1929 cells, with IC50 values of 62 nM and 8.5 μM, respectively [1].
价 格：￥电议型 号：T73957产 地：中国大陆
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T73941PROTAC BCR-ABL1 ligand 1；化合物 PROTAC BCR-ABL1 ligand 1PROTAC BCR-ABL1 ligand 1
GMB-475, also known as PROTAC BCR-ABL1 ligand 1, allosterically targets and binds to the BCR-ABL1 protein. It effectively recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and subsequent degradation of BCR-ABL1 [1].
价 格：￥电议型 号：T73941产 地：中国大陆
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T73869BCL6 PROTAC 1；化合物 BCL6 PROTAC 1BCL6 PROTAC 1
BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 value of 8.8 ?M and significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines, making it valuable for tumor-related research [1].
价 格：￥电议型 号：T73869产 地：中国大陆
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T73868PROTAC BTK Degrader-2；化合物 PROTAC BTK Degrader-2PROTAC BTK Degrader-2
PROTAC BTK Degrader-2, a potent degrader of BTK through the PROTAC mechanism, effectively diminishes BTK protein levels [1].
价 格：￥电议型 号：T73868产 地：中国大陆
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T73835PROTAC HSP90 degrader BP3；化合物 PROTAC HSP90 degrader BP3PROTAC HSP90 degrader BP3
PROTAC HSP90 degrader BP3 potently and selectively degrades HSP90 through a CRBN-dependent mechanism. It effectively diminishes HSP90 protein levels in MCF-7 cells with a half-maximal degradation concentration (DC50) of 0.99 ?M. Additionally, this compound impedes the proliferation of breast cancer cells [1].
价 格：￥电议型 号：T73835产 地：中国大陆
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T73726PROTAC AR Degrader-4 TFA；化合物 PROTAC AR Degrader-4 TFAPROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4, an Androgen Receptor (AR) degrader, incorporates an IAP ligand binding group, a linker, and an AR binding group. It represents a class of degradation inducers known as specific and non-genetic IAP-dependent protein erasers (SNIPERs) [1], operating through a mechanism involving cIAP1.
价 格：￥电议型 号：T73726产 地：中国大陆
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T64739HaloPROTAC-E；化合物 HaloPROTAC-EHaloPROTAC-E
HaloPROTAC-E is a useful organic compound for research related to life sciences and the catalog number is T64739.
价 格：￥电议型 号：T64739产 地：中国大陆
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T64284PROTAC CDK12/13 Degrader-1；化合物 PROTAC CDK12/13 Degrader-1PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) is a potent and selective dual degrader of the cell cycle protein-dependent kinases CDK12 (DC50: 2.2 nM) and CDK13 (DC50: 2.1 nM). Breast cancer.
价 格：￥电议型 号：T64284产 地：中国大陆
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T5835PROTAC ERRα ligand 2；化合物PROTAC ERRα ligand 2PROTAC ERRα ligand 2
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
价 格：￥电议型 号：T5835产 地：中国大陆
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T5438PROTAC CDK9 Degrader-1；化合物PROTAC CDK9 Degrader-1PROTAC CDK9 Degrader-1
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
价 格：￥电议型 号：T5438产 地：中国大陆
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T5437Gefitinib-based PROTAC 3；化合物Gefitinib-based PROTAC 3Gefitinib-based PROTAC 3
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].
价 格：￥电议型 号：T5437产 地：中国大陆
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T41267PROTAC(H-PGDS)-7；化合物 PROTAC(H-PGDS)-7PROTAC(H-PGDS)-7
PROTAC(H-PGDS)-7 is a selective and potent small molecule hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degradation agent that exhibits degradation activity in KU812 cells with a DC50 of 17.3 pM. PROTAC(H-PGDS)-7 is a pharmacological compound that effectively inhibits prostaglandin D2 (PGD2) PROTAC(H-PGDS)-7 is a candidate compound for the treatment of DMD and other H-PGDS-related diseases.
价 格：￥电议型 号：T41267产 地：中国大陆
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T40334PROTAC IRAK3 degrade-1；PROTAC IRAK3 degrade-1PROTAC IRAK3 degrade-1；PROTAC IRAK3 degrade-1
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).
价 格：￥电议型 号：T40334产 地：中国大陆
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T40143PROTAC CBP/P300 Degrader-1；PROTAC CBP/P300 Degrader-1PROTAC CBP/P300 Degrader-1；PROTAC CBP/P300 Degr
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
价 格：￥电议型 号：T40143产 地：中国大陆
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T40112PROTAC PD-1/PD-L1 degrader-1；PROTAC PD-1/PD-L1 degrader-1PROTAC PD-1/PD-L1 degrader-1；PROTAC PD-1/PD
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
价 格：￥电议型 号：T40112产 地：中国大陆
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T40075PROTAC BRD4 Degrader-13；PROTAC BRD4 Degrader-13PROTAC BRD4 Degrader-13；PROTAC BRD4 Degrader-13
PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cells, this compound effectively degrades the BRD4 protein through conjugation with STEAP1 and CLL1 antibodies. The degradation of BRD4 protein is achieved with remarkable potency, exhibiting a DC 50 of 0.025 nM and 6.0 nM when combined with STEAP1 and CLL1 antibodies, respectively.
价 格：￥电议型 号：T40075产 地：中国大陆
