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T62058αβ-Tubulin-IN-1；化合物 αβ-Tubulin-IN-1αβ-Tubulin-IN-1
αβ-Tubulin-IN-1 is a potent and orally active inhibitor of αβ-Tubulin. αβ- Tubulin-IN-1 blocks cell cycle at G2/M phase and induces apoptosis. αβ-Tubulin-IN-1 inhibits tumor cell migration and metastasis. αβ-Tubulin-IN-1 exhibits significant antitumor efficacy.
价 格：￥电议型 号：T62058产 地：中国大陆
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T61958MAO A/HDAC-IN-1；化合物 MAO A/HDAC-IN-1MAO A/HDAC-IN-1
MAO A/HDAC-IN-1 is an effective monoamine oxidase A (MAO A) and HDAC dual inhibitor, which can be used for glioma research.
价 格：￥电议型 号：T61958产 地：中国大陆
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T6193Dovitinib Dilactic Acid；化合物Dovitinib Dilactic AcidDovitinib (TKI-258) Dilactic Acid|||TKI258 Dilacti
Dovitinib Dilactic Acid (Dovitinib (TKI-258) Dilactic Acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
价 格：￥电议型 号：T6193产 地：中国大陆
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T61858HDAC8-IN-3；化合物 HDAC8-IN-3HDAC8-IN-3
HDAC8-IN-3 (compound P19) is a highly potent inhibitor of HDAC8, displaying an IC50 value of 9.3 μM and producing thermal stabilization. Moreover, HDAC8-IN-3 exhibits cytotoxicity and induces apoptosis specifically in leukemic cell lines [1].
价 格：￥电议型 号：T61858产 地：中国大陆
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T61758HP1328；化合物 HP1328HP1328
HP1328 is a highly effective inhibitor of FLT3 receptor tyrosine kinase with a specific focus on FLT3/ITD mutation. It belongs to the benzoimidazole scaffold-based compound family. Significantly reducing the leukemia burden, HP1328 effectively extends the survival of mice afflicted with FLT3/ITD leukemia [1].
价 格：￥电议型 号：T61758产 地：中国大陆
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T6175ADL-5859；化合物ADL5859 HClADL5859 Hydrochloride|||ADL5859 HCl；ADL5859 Hydrochloride|||ADL5859 HCl
ADL-5859 (ADL5859 Hydrochloride) is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.
价 格：￥电议型 号：T6175产 地：中国大陆
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T61724SB 258741 hydrochloride；化合物 SB 258741 hydrochlorideSB 258741 hydrochloride
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].
价 格：￥电议型 号：T61724产 地：中国大陆
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T61663SBI-581；化合物 SBI-581SBI-581
SBI-581 is an orally active, potent selective inhibitor of serine-threonine kinase TAO3, with an IC 50 of 42 nM. It effectively promotes the accumulation of TKS5α at RAB11-positive vesicles and inhibits the formation of invadopodia. Additionally, SBI-581 exhibits reasonable pharmacokinetics in mice when administered via IP injection, demonstrating significant antitumor activity [1].
价 格：￥电议型 号：T61663产 地：中国大陆
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T61658TYK2-IN-11；化合物 TYK2-IN-11TYK2-IN-11
TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advancing research in the area of inflammatory and autoimmune diseases [1].
价 格：￥电议型 号：T61658产 地：中国大陆
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T6159LY-2584702 free base；化合物LY-2584702LY-2584702 free base
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
价 格：￥电议型 号：T6159产 地：中国大陆
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T61589c-Fms-IN-13；化合物c-Fms-IN-13c-Fms-IN-13
c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.
价 格：￥电议型 号：T61589产 地：中国大陆
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T61588AGN 192870；化合物AGN 192870AGN 192870
AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.
价 格：￥电议型 号：T61588产 地：中国大陆
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T61587ATR-IN-15；化合物 ATR-IN-15ATR-IN-15
ATR-IN-15 (compound 1) is a highly potent and orally active inhibitor of ATR kinase with an IC50 of 8 nM. Additionally, ATR-IN-15 demonstrates inhibitory activity against several targets, including human colon tumor cells LoVo, DNA-PK, and PI3K, with IC50 values of 47, 663, and 5131 nM, respectively [1].
价 格：￥电议型 号：T61587产 地：中国大陆
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T61586TGFβ-IN-2；化合物 TGFβ-IN-2TGFβ-IN-2
TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and p-Smad3, which are induced by TGF-β. Additionally, TGFβ-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].
价 格：￥电议型 号：T61586产 地：中国大陆
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T61585Sulindac sodium；化合物 Sulindac sodiumSulindac sodium
Sulindac (sodium) (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac (sodium) is used to reduce pain, swelling, and joint stiffness from arthritis. Sulindac is also used for the research of arthritis of the spine, gouty arthritis. Sulindac (sodium), as an immunomodulatory agent, can downregulate PD-L1 through the blockade of NF-κB signaling and modulates the response of pMMR colorectal cancer (CRC) to anti-PD-L1 immunotherapy, inhibits the development and progression of
价 格：￥电议型 号：T61585产 地：中国大陆
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T61584ASK1-IN-3；化合物 ASK1-IN-3ASK1-IN-3
ASK1-IN-3 is a highly potent and selective inhibitor of ASK1 kinase, demonstrating an IC 50 of 33.8 nM. This compound also exhibits inhibitory effects on various cell cycle regulating kinases. ASK1-IN-3 showcases remarkable induction of apoptosis in HepG2 cancer cells and displays potent activity in arresting the cell cycle [1].
价 格：￥电议型 号：T61584产 地：中国大陆
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T61583CDK/HDAC-IN-1；化合物 CDK/HDAC-IN-1CDK/HDAC-IN-1
CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively.
价 格：￥电议型 号：T61583产 地：中国大陆
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T61582Anticancer agent 57；化合物 Anticancer agent 57Anticancer agent 57
Anticancer agent 57 (compound 14) demonstrates potent inhibition of MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC 50 values ranging from 6.43 to 8.00 μM. Additionally, this agent induces cell cycle arrest and promotes apoptosis. In vivo studies using nude mice xenografted with MADMB-231 cells have shown that Anticancer agent 57 effectively inhibits tumor growth. Consequently, Anticancer agent 57 can serve as a valuable tool for researching triple negative breast cancer (TNBC) [1].
价 格：￥电议型 号：T61582产 地：中国大陆
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T61581LasR-IN-2；化合物 LasR-IN-2LasR-IN-2
LasR-IN-2, a compound that inhibits the activity of LasR, forms hydrogen bonding with the TRY-56 residue. It finds application in the study of bacterial infection, neutropenia, severe burns, and chronic lung disease in cystic fibrosis (CF) [1].
价 格：￥电议型 号：T61581产 地：中国大陆
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T61580Autophagy inducer 3；化合物 Autophagy inducer 3Autophagy inducer 3
Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autophagic cell death in various cancer cells while sparing normal cells. This compound induces lethal autophagy through the formation of distinct autophagic vacuoles, LC3 puncta formation, and upregulation of signature autophagy markers such as Beclin and Atg family proteins [1].
价 格：￥电议型 号：T61580产 地：中国大陆
