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  • T11430Glycosidase-IN-1；化合物 T11430Glycosidase-IN-1

    Glycosidase-IN-1 is a glycosidase inhibitor synthesized from D-mannose with hypoglycemic activity. It can be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors.

    价 格：￥电议型 号：T11430产 地：中国大陆

  • T11421Glutaminase-IN-1；谷氨酰胺酶抑制剂1CB839 derivative；CB839 derivative

    Glutaminase-IN-1 (CB839 derivative), a novel 1,3,4-selenodiazepine renal-type glutaminase (KGA) variant inhibitor, showed antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.

    价 格：￥电议型 号：T11421产 地：中国大陆

  • T11412IPN60090；化合物IPN60090GLS1-IN-1；GLS1-IN-1

    IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.

    价 格：￥电议型 号：T11412产 地：中国大陆

  • T11373GCN2-IN-1；化合物GCN2-IN-1A-92；A-92

    GCN2-IN-1 (A-92) is an effective GCN2 inhibitor and can be used in research on the treatment of cancer as a chemotherapeutic agent.

    价 格：￥电议型 号：T11373产 地：中国大陆

  • T11368GATA4-NKX2-5-IN-1；化合物GATA4-NKX2-5-IN-1GATA4-NKX2-5-IN-1

    GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression.GATA4-NKX2-5-IN-1 ?dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM.

    价 格：￥电议型 号：T11368产 地：中国大陆

  • T11341FXIa-IN-1；化合物 T11341FXIa-IN-1

    FXIa-IN-1 is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.

    价 格：￥电议型 号：T11341产 地：中国大陆

  • T11337Fumarate hydratase-IN-1；Fumarate hydratase 抑制剂1Fumarate hydratase-IN-1

    Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor with antiproliferative activity and can be used to study cellular activity.

    价 格：￥电议型 号：T11337产 地：中国大陆

  • T11332FUBP1-IN-1；化合物 T11332FUBP1–IN-1；FUBP1–IN-1

    FUBP1 - in-1, with an IC50 value of 11.0 M, is an effective FUSE binding protein 1 (FUBP1) inhibitor that can interfere with the binding of FUBP1 to its SINGLE-strand target DNA FUSE sequence.

    价 格：￥电议型 号：T11332产 地：中国大陆

  • T11269FD-IN-1；化合物 T11269FD-IN-1

    FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system.

    价 格：￥电议型 号：T11269产 地：中国大陆

  • T11267FASN-IN-1；化合物FASN-IN-1TVB-2460；TVB-2460

    FASN-in-1 is an effective, specific inhibitor of fatty acid synthase (FASN), a compound specifically designed to target and inhibit the activity of the enzyme involved in fatty acid synthesis, potentially disrupting fatty acid production and affecting various cellular processes.

    价 格：￥电议型 号：T11267产 地：中国大陆

  • T11266LFAS-IN-1 Tosylate；化合物 T11266LFAS-IN-1 Tosylate

    FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.

    价 格：￥电议型 号：T11266L产 地：中国大陆

  • T11266FASN-IN-4；化合物 T11266FAS-IN-1；FAS-IN-1

    FAS-IN-1 is a potent inhibitor of Fatty acid synthase (FAS) wtih IC50 of 10 nM.

    价 格：￥电议型 号：T11266产 地：中国大陆

  • T11255FAAH-IN-1；化合物 T11255FAAH-IN-1

    FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.

    价 格：￥电议型 号：T11255产 地：中国大陆

  • T11224Rineterkib；化合物RineterkibERK-IN-1；ERK-IN-1

    Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

    价 格：￥电议型 号：T11224产 地：中国大陆

  • T11221ERAP1-IN-1；化合物ERAP1-IN-1ERAP1-IN-1

    ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates.

    价 格：￥电议型 号：T11221产 地：中国大陆

  • T11170eIF4A3-IN-1；化合物 T11170eIF4A3-IN-1

    eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.

    价 格：￥电议型 号：T11170产 地：中国大陆

  • T11166EHMT2-IN-1；化合物 T11166EHMT2-IN-1

    EHMT2-IN-1 is a potent EHMT inhibitor, . Used in the research of blood disorder or cancer.with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.

    价 格：￥电议型 号：T11166产 地：中国大陆

  • T11164EGFR mutant-IN-1；化合物 T11164EGFR mutant-IN-1

    EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantly weakened EGFRWT effect.

    价 格：￥电议型 号：T11164产 地：中国大陆

  • T11158EGFR-IN-11；化合物EGFR-IN-11EGFR-IN-11

    EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.

    价 格：￥电议型 号：T11158产 地：中国大陆

  • T11157LEGFR-IN-1 hydrochloride；EGFR-IN-1盐酸盐EGFR-IN-1 hydrochloride

    EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochloride exhibits potent antitumor and antiproliferative activity in H1975 cells and the mutant HCC827 cells with IC50s of 4 and 28 nM, respectively.

    价 格：￥电议型 号：T11157L产 地：中国大陆

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