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  • T11157EGFR-IN-1；化合物 T11157EGFR-IN-1

    EGFR-IN-1, an orally active and irreversible selective inhibitor targeting L858R/T790M mutant EGFR, exhibits strong antiproliferative and antitumor activity, particularly against H1975 cells and first line mutant HCC827 cells. This compound potently inhibits Gefitinib-resistant EGFR L858R/T790M mutations with a 100-fold selectivity over the wild-type EGFR.

    价 格：￥电议型 号：T11157产 地：中国大陆

  • T11132DYRKs-IN-1；化合物 T11132DYRKs-IN-1

    DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively.

    价 格：￥电议型 号：T11132产 地：中国大陆

  • T11110DUB-IN-1；化合物DUB-IN-1DUB-IN-1

    DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).

    价 格：￥电议型 号：T11110产 地：中国大陆

  • T11094DRAK2-IN-1；化合物 T11094DRAK2-IN-1

    Drak2-in-1, a potent, selective and ATP-competitive DRAK2 inhibitor, has an IC50 and KIvalue of 3 nM and 0.26 nM, respectively.Drak2-in-1 also had an effect on DRAK1 (IC50=51 nM).

    价 格：￥电议型 号：T11094产 地：中国大陆

  • T11081Dot1L-IN-1；化合物 T11081Dot1L-IN-1

    The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.

    价 格：￥电议型 号：T11081产 地：中国大陆

  • T11056DLK-IN-1；化合物 T11056DLK-IN-1

    DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer´s disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration exceeds the concentration required for DLK inhibition in the brain, so it has good tolerance Acceptability.

    价 格：￥电议型 号：T11056产 地：中国大陆

  • T11024DHODH-IN-15；化合物DHODH-IN-15DHODH-IN-15

    DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.

    价 格：￥电议型 号：T11024产 地：中国大陆

  • T11023DHODH-IN-14；化合物DHODH-IN-14DHODH-IN-14

    DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.

    价 格：￥电议型 号：T11023产 地：中国大陆

  • T11022DHODH-IN-13；化合物DHODH-IN-13DHODH-IN-13

    DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.

    价 格：￥电议型 号：T11022产 地：中国大陆

  • T11021DHODH-IN-12；化合物DHODH-IN-12DHODH-IN-12

    DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.

    价 格：￥电议型 号：T11021产 地：中国大陆

  • T11020DHODH-IN-11；化合物DHODH-IN-11DHODH-IN-11

    DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.

    价 格：￥电议型 号：T11020产 地：中国大陆

  • T11019DHODH-IN-1；化合物DHODH-IN-1DHODH-IN-1

    DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.

    价 格：￥电议型 号：T11019产 地：中国大陆

  • T10954DAGLβ-IN-1；化合物DAGLβ-IN-1DAGLβ-IN-1

    DAGLβ-IN-1 is a universal intermediate for designing DAGL tailored activity-based probes, and is an inhibitor of diacylglycerol lipase-β (DAGLβ).

    价 格：￥电议型 号：T10954产 地：中国大陆

  • T10923CYP17-IN-1；化合物CYP17-IN-1CYP17-IN-1

    CYP17-IN-1 is an effective oral inhibitor of CYP17 that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.

    价 格：￥电议型 号：T10923产 地：中国大陆

  • T10918NEP-IN-1；化合物NEP-In-1NEP-IN-1

    NEP-IN-1 is an inhibitor of neutral endopeptidase (NEP, IC50 = 2 nM) and can be used in studies about female sexual arousal disorders.

    价 格：￥电议型 号：T10918产 地：中国大陆

  • T10917LTB4-IN-1；化合物LTB4-IN-1Anti-inflammatory agent 2；Anti-inflammatory agent 2

    LTB4-IN-1 (Anti-inflammatory agent 2) with IC50 of 70 nM is an inhibitor of leukotriene synthesis (LTB4).

    价 格：￥电议型 号：T10917产 地：中国大陆

  • T10905CXCR2-IN-1；化合物CXCR2-IN-1CXCR2-IN-1

    CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.

    价 格：￥电议型 号：T10905产 地：中国大陆

  • T10894CSF1R-IN-1；化合物CSF1R-IN-1CSF1R-IN-1

    CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.

    价 格：￥电议型 号：T10894产 地：中国大陆

  • T10891CRTH2-IN-1；化合物 T10891Ramatroban analog；Ramatroban analog

    CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.

    价 格：￥电议型 号：T10891产 地：中国大陆

  • T10863Complement C5-IN-1；化合物Complement C5-IN-1Complement C5-IN-1

    Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).

    价 格：￥电议型 号：T10863产 地：中国大陆

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