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  • T8685SP-146；化合物SP-146SP-146

    SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).

    价 格：￥电议型 号：T8685产 地：中国大陆

  • T83948Sakura 6；化合物 Sakura 6Sakura 6

    Sakura 6, a synthetic serotonin transporter (SERT)-binding peptide, enhances the interaction between SERT and neuronal nitric oxide synthase. This interaction decreases SERT activity and its presence on the cell surface, augments auto-inhibition, lowers synaptic 5-HT release, and diminishes activity in the dorsal raphe nucleus, ultimately inducing an acute depressive phenotype in a mouse depression model.

    价 格：￥电议型 号：T83948产 地：中国大陆

  • T83930SJ 11646；化合物 SJ 11646SJ 11646

    SJ 11646, a potent lymphocyte-specific protein tyrosine kinase (LCK) Degrader (PROTAC) with a DC50 of 0.00838 pM, utilizes Dasatinib as the LCK ligand and incorporates a phenyl glutarimide-based cereblon binder. Demonstrating cytotoxicity in both LCK-activated T cell acute lymphoblastic leukemia (T-ALL) cell lines and primary leukemia samples in vitro, SJ 11646 also exhibits anti-leukemic efficacy in vivo within patient-derived xenograft models of T-ALL.

    价 格：￥电议型 号：T83930产 地：中国大陆

  • T83630STM3006；化合物 STM3006STM3006

    STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).

    价 格：￥电议型 号：T83630产 地：中国大陆

  • T8357SB-200646；化合物SB-200646SB-200646

    SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor

    价 格：￥电议型 号：T8357产 地：中国大陆

  • T81719N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine；化合物 N-[(6S)-6-Carboxy-6-(glycylamino)h

    N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine functions as an inhibitor of the PAICS protein, effectively decreasing the accumulation of both SAICAR and SAICAr.

    价 格：￥电议型 号：T81719产 地：中国大陆

  • T81217SAP6；化合物 SAP6SAP6

    SAP6 is a bioactive peptide that inhibits virus entry into cells.

    价 格：￥电议型 号：T81217产 地：中国大陆

  • T81205SARS-CoV-2-IN-66；化合物 SARS-CoV-2-IN-66SARS-CoV-2-IN-66

    SARS-CoV-2-IN-66 (1), a derivative of vitamin K, functions as an inhibitor of SARS-CoV-2, exhibiting an effective concentration (EC50) of 70.8 μM in VeroE6/TMPRSS2 cells [1].

    价 格：￥电议型 号：T81205产 地：中国大陆

  • T81144SMP-93566；化合物 SMP-93566SMP-93566

    SMP-93566 is an antibody-drug conjugate (ADC) characterized by a low payload shedding rate, demonstrating in vivo tumor suppression in ovarian, gastric, and breast cancers [1].

    价 格：￥电议型 号：T81144产 地：中国大陆

  • T81137SNX7886；化合物 SNX7886SNX7886

    SNX7886 is a potent PROTAC (proteolysis-targeting chimera) that effectively degrades CDK8 and CDK19, achieving 90% degradation of CDK8 and 80% degradation of CDK19 in 293 cells [1].

    价 格：￥电议型 号：T81137产 地：中国大陆

  • T81090Steroid sulfatase-IN-6；化合物 Steroid sulfatase-IN-6Steroid sulfatase-IN-6

    Steroid Sulfatase-IN-6 (Compound 10c) serves as an irreversible steroid sulfatase (STS) inhibitor, exhibiting a K i value of 0.4 nM against human placenta STS, and is applicable in tumor disease research [1].

    价 格：￥电议型 号：T81090产 地：中国大陆

  • T79816S1P1 agonist 6；化合物 S1P1 agonist 6S1P1 agonist 6

    Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive agent in autoimmune disease research [1].

    价 格：￥电议型 号：T79816产 地：中国大陆

  • T79708SSE1806；化合物 SSE1806SSE1806

    SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and antiproliferative properties. It demonstrates a GI50 for inhibiting cancer cell growth between 1.29-21.15 μM. This compound induces mitotic disruption and G2/M phase arrest, upregulates p53 expression, and suppresses the growth of colon cancer organoids. Notably, SSE1806 can counteract multidrug resistance in cell lines that overexpress MDR-1 [1].

    价 格：￥电议型 号：T79708产 地：中国大陆

  • T79659SARS-CoV-2 3CLpro-IN-16；SARS-CoV-2 3CLpro 抑制剂16SARS-CoV-2 3CLpro-IN-16

    SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.

    价 格：￥电议型 号：T79659产 地：中国大陆

  • T79544SDH-IN-6；化合物 SDH-IN-6SDH-IN-6

    SDH-IN-6 (compound 6i), a potent inhibitor of succinate dehydrogenase (SDH), exhibits antifungal efficacy against Valsa mali, demonstrated by an EC50 value of 1.77 mg/L [1].

    价 格：￥电议型 号：T79544产 地：中国大陆

  • T79477SCAL-266；化合物 SCAL-266SCAL-266

    SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 μM. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (OCR), increasing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP). Furthermore, SCAL-266 demonstrates significant antiproliferative activity against OXPHOS-dependent cancer cells [1].

    价 格：￥电议型 号：T79477产 地：中国大陆

  • T79412SHP2-IN-16；化合物 SHP2-IN-16SHP2-IN-16

    SHP2-IN-16 (compound 222) is a potent SHP2 inhibitor exhibiting an IC50 of 1 nM, and is applicable in glioblastoma research [1].

    价 格：￥电议型 号：T79412产 地：中国大陆

  • T79329SARS-CoV-2-IN-56；化合物 SARS-CoV-2-IN-56SARS-CoV-2-IN-56

    SARS-CoV-2-IN-56 (Compound 63) is a SARS-CoV-2 inhibitor with antiviral activity, demonstrating inhibition of the virus in Vero E6 cells with an IC50 of 0.7 μM [1].

    价 格：￥电议型 号：T79329产 地：中国大陆

  • T79258sEH inhibitor-16；化合物 sEH inhibitor-16sEH inhibitor-16

    sEH Inhibitor-16, a potent soluble epoxide hydrolase (sEH) inhibitor, exhibits an IC50 of 2 nM. It diminishes inflammatory damage associated with cerulein-induced acute pancreatitis (AP) in mice, making it suitable for inflammation and immunology research [1].

    价 格：￥电议型 号：T79258产 地：中国大陆

  • T79183SOS1-IN-16；化合物 SOS1-IN-16SOS1-IN-16

    SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of 8.9μM when testosterone is employed as a substrate. This compound is utilized in cancer research [1].

    价 格：￥电议型 号：T79183产 地：中国大陆

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