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  • T78822JT002；化合物 JT002JT002

    JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLRP3 inflammasome complex. Additionally, JT002 mitigates airway hyperresponsiveness and airway neutrophilia in mice [1].

    价 格：￥电议型 号：T78822产 地：中国大陆

  • T78821IHC3；化合物 IHC3IHC3

    IHC3 is a competitive and reversible monoamine oxidase B (MAO-B) inhibitor with an IC50 of 1.672 μM, which targets Cys172 within the enzyme´s active site. It is utilized in the study of neurological diseases [1].

    价 格：￥电议型 号：T78821产 地：中国大陆

  • T788205-LOX-IN-5；化合物 5-LOX-IN-55-LOX-IN-5

    Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in research pertaining to neurodegenerative diseases [1].

    价 格：￥电议型 号：T78820产 地：中国大陆

  • T7882Indomethacin farnesil；吲哚美辛法呢酯Infree；吲哚美辛法呢酯|||Infree

    Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD).

    价 格：￥电议型 号：T7882产 地：中国大陆

  • T78819VEGFR-2-IN-33；化合物 VEGFR-2-IN-33VEGFR-2-IN-33

    VEGFR-2-IN-33 (Compound 4d), a potent VEGFR inhibitor with an IC50 value of 61.04 nM, demonstrates significant inhibition of HepG2 cell proliferation, achieving an IC50 of 4.31 nM. This compound is utilized for hepatocellular carcinoma (HCC) research [1].

    价 格：￥电议型 号：T78819产 地：中国大陆

  • T78818HDAC-IN-63；化合物 HDAC-IN-63HDAC-IN-63

    HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1. It effectively suppresses MV4-11 cell proliferation with an IC50 of 92 nM, induces apoptosis, and arrests the cell cycle in MV4-11 cells. This compound is applied in acute myeloid leukemia (AML) research [1].

    价 格：￥电议型 号：T78818产 地：中国大陆

  • T78817AChE-IN-39；化合物 AChE-IN-39AChE-IN-39

    AChE-IN-39 (Compound 7c), with an IC50 value of 0.058 μM, is an acetylcholinesterase (AChE) inhibitor known for its DPPH scavenging activity and potential to ameliorate cognitive impairments in an aluminum chloride (AlCl3)-induced amnesia animal model, suggesting its usefulness in Alzheimer´s disease research [1].

    价 格：￥电议型 号：T78817产 地：中国大陆

  • T78816Anti-osteoporosis agent-4；化合物 Anti-osteoporosis agent-4Anti-osteoporosis agent-4

    Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively inhibits osteoclast formation, demonstrating an IC50 value of 358.29 nM, and impedes the activation of the PI3K/AKT and IκBα/NF-κB signaling pathways [1].

    价 格：￥电议型 号：T78816产 地：中国大陆

  • T78815MOZ-IN-3；化合物 MOZ-IN-3MOZ-IN-3

    MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemia cell lines, including HL-60, U937, SKNO-1, and K562. This compound also demonstrates favorable metabolic stability and pharmacokinetics [1].

    价 格：￥电议型 号：T78815产 地：中国大陆

  • T78814COH1；化合物 COH1COH1

    COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].

    价 格：￥电议型 号：T78814产 地：中国大陆

  • T78813CDK2/Bcl2-IN-1；化合物 CDK2/Bcl2-IN-1CDK2/Bcl2-IN-1

    CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells. Additionally, it inhibits Bcl-2 and promotes apoptosis in A549 lung cancer cells [1].

    价 格：￥电议型 号：T78813产 地：中国大陆

  • T78812HBV-IN-36；化合物 HBV-IN-36HBV-IN-36

    HBV-IN-36 (also known as compound 42) is a hepatitis B virus (HBV) inhibitor with an IC50 of 2 μM, exhibiting anti-HBV activity characterized by an EC50 of 0.58 μM [1].

    价 格：￥电议型 号：T78812产 地：中国大陆

  • T78811PROTAC AR-NTD degrader 1；化合物 PROTAC AR-NTD degrader 1PROTAC AR-NTD degrader 1

    PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antagonizing AR-NTD, this compound effectively degrades AR-V7 protein and triggers apoptosis in prostate cancer (PC) cells, with degradation efficiencies in VCaP cells recorded at 62.2% (1 μM) and 71.1% (5 μM), as noted in reference [1].

    价 格：￥电议型 号：T78811产 地：中国大陆

  • T78810BWA-522；化合物 BWA-522BWA-522

    BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL) and the AR-V7 splice variant. It specifically antagonizes the N-terminal domain (AR-NTD) of the androgen receptor (Androgen Receptor), prompting apoptosis in prostate cancer (PC) cells. In LNCaP xenograft models, BWA-522 demonstrated tumor growth inhibition (60 mg/kg, po; TGI=76%). The compound effectively reduced levels of AR-V7 and AR-FL

    价 格：￥电议型 号：T78810产 地：中国大陆

  • T7881CTP disodium dihydrate；胞苷-5’-三磷酸二钠盐(二水)CTP disodium dihydrate

    CTP disodium dihydrate is an agonist of P2X4 purinergic receptor

    价 格：￥电议型 号：T7881产 地：中国大陆

  • T78809NDNA3；化合物 NDNA3NDNA3

    NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cells, with IC50 values of 12.66 μM and 11.72 μM respectively. It stabilizes hERG channel maturation without eliciting a heat shock response or degrading Hsp90α-dependent client proteins [1].

    价 格：￥电议型 号：T78809产 地：中国大陆

  • T78808NDNA4；化合物 NDNA4NDNA4

    NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability. It exhibits minimal cytotoxicity against Ovcar-8 and MCF-10A cell lines (IC50 >100 μM) and maintains hERG channel maturation without eliciting a heat shock response or degrading Hsp90α-dependent client proteins [1].

    价 格：￥电议型 号：T78808产 地：中国大陆

  • T78807YIAD-0205；化合物 YIAD-0205YIAD-0205

    YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial AD mutations [1].

    价 格：￥电议型 号：T78807产 地：中国大陆

  • T78806PPARδ agonist 9；化合物 PPARδ agonist 9PPARδ agonist 9

    PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic development in the LDLr-KO model with an inhibition rate of 50-60% [1].

    价 格：￥电议型 号：T78806产 地：中国大陆

  • T78805AD4；化合物 AD4AD4

    AD4, an artemisinin derivative functioning as a proteolytic targeting chimera (PROTAC) for PCLAF, effectively degrades PCLAF in RS4;11 cells with an IC50 of 0.6 nM. This degradation activates the p21/Rb axis, resulting in antitumor activity. Furthermore, AD4 has been demonstrated to prolong survival in NOD/SCID mice transplanted with RS4;11 cells, showcasing its in vivo efficacy [1].

    价 格：￥电议型 号：T78805产 地：中国大陆

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