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T40074PROTAC BRD4 Degrader-15；PROTAC BRD4 Degrader-15PROTAC BRD4 Degrader-15；PROTAC BRD4 Degrader-15
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
价 格：￥电议型 号：T40074产 地：中国大陆
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T40073PROTAC BRD4 Degrader-10；PROTAC BRD4 Degrader-10PROTAC BRD4 Degrader-10；PROTAC BRD4 Degrader-10
PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies, with respective DC 50 values of 1.3 nM and 18 nM.
价 格：￥电议型 号：T40073产 地：中国大陆
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T40072PROTAC BRD4 Degrader-9；PROTAC BRD4 Degrader-9PROTAC BRD4 Degrader-9；PROTAC BRD4 Degrader-9
PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate cancer cells. When conjugated with STEAP1 and CLL1 antibodies, PROTAC BRD4 Degrader-9 exhibits potent activity, with respective DC50 values of 0.86 nM and 7.6 nM.
价 格：￥电议型 号：T40072产 地：中国大陆
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T39997PROTAC CDK9 ligand-1；PROTAC CDK9 ligand-1PROTAC CDK9 ligand-1；PROTAC CDK9 ligand-1
PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
价 格：￥电议型 号：T39997产 地：中国大陆
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T39996PROTAC CDK9 degrader-4；PROTAC CDK9 degrader-4PROTAC CDK9 degrader-4；PROTAC CDK9 degrader-4
PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9, thereby modulating transcriptional activity.
价 格：￥电议型 号：T39996产 地：中国大陆
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T39920PROTAC IRAK4 degrader-3；PROTAC IRAK4 degrader-3PROTAC IRAK4 degrader-3；PROTAC IRAK4 degrader-3
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
价 格：￥电议型 号：T39920产 地：中国大陆
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T39903PROTAC IRAK4 degrader-6；PROTAC IRAK4 degrader-6PROTAC IRAK4 degrader-6；PROTAC IRAK4 degrader-6
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
价 格：￥电议型 号：T39903产 地：中国大陆
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T39902PROTAC IRAK4 degrader-5；PROTAC IRAK4 degrader-5PROTAC IRAK4 degrader-5；PROTAC IRAK4 degrader-5
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
价 格：￥电议型 号：T39902产 地：中国大陆
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T39901PROTAC IRAK4 degrader-4；PROTAC IRAK4 degrader-4PROTAC IRAK4 degrader-4；PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
价 格：￥电议型 号：T39901产 地：中国大陆
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T39837PROTAC ERRα Degrader-3；PROTAC ERRα Degrader-3PROTAC ERRα Degrader-3
PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capability, reducing the ERRα protein levels by >80%. Importantly, PROTAC ERRα Degrader-3 shows no activity against the ERRβ and ERRγ proteins.
价 格：￥电议型 号：T39837产 地：中国大陆
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T39628PROTAC BRD4 ligand-2；PROTAC BRD4 ligand-2PROTAC BRD4 ligand-2；PROTAC BRD4 ligand-2
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718.
价 格：￥电议型 号：T39628产 地：中国大陆
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T39374PROTAC BET Degrader-10；PROTAC BET Degrader-10PROTAC BET Degrader-10
PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that connect Cereblon and BRD4, with a DC 50 value of 49 nM.
价 格：￥电议型 号：T39374产 地：中国大陆
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T37329PROTAC IDO1 Degrader-1；PROTAC IDO1 Degrader-1PROTAC IDO1 Degrader-1；PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].
价 格：￥电议型 号：T37329产 地：中国大陆
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T36628PROTAC BRD4 Degrader-8；PROTAC BRD4 Degrader-8PROTAC BRD4 Degrader-8；PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].
价 格：￥电议型 号：T36628产 地：中国大陆
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T36256LC-2；化合物LC-2LC 2|||PROTAC KRASG12C Degrader-LC-2|||LC2；LC 2|||PROTAC KRASG12C Degrader-LC-2|||LC2
LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recruits the E3 ligase, VH, to induce a rapid and sustained degradation of KRAS G12C. LC-2 inhibits MAPK signaling in pure and heterozygous KRAS G12C cell lines.
价 格：￥电议型 号：T36256产 地：中国大陆
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T36247TBK1 control PROTAC? 4；TBK1 control PROTAC? 4TBK1 control PROTAC? 4
Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
价 格：￥电议型 号：T36247产 地：中国大陆
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T36243PROTAC RIPK degrader-6；PROTAC RIPK degrader-6PROTAC RIPK degrader-6
PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker to a cereblon binder[1].
价 格：￥电议型 号：T36243产 地：中国大陆
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T36242PROTAC BRD4 Degrader-5PROTAC BRD4 Degrader-5PROTAC BRD4 Degrader-5
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
价 格：￥电议型 号：T36242产 地：中国大陆
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T34168PROTAC-I；化合物 T34168PROTAC I；PROTAC I
PROTAC-I targets steroid hormone receptors for ubiquitination and degradation.
价 格：￥电议型 号：T34168产 地：中国大陆
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T34166PROTAC_ERRalpha；化合物 T34166PROTAC_ERRalpha
PROTAC_ERRalpha is a proteolysis targeting chimeras (PROTAC) which provides broad tissue distribution and knockdown of the targeted ERRalpha protein in tumor xenografts.
价 格：￥电议型 号：T34166产 地：中国大陆
