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T62907TAS-117 hydrochloride；化合物 TAS-117 hydrochlorideTAS-117 hydrochloride
TAS-117 hydrochloride is a selective, potent, orally active allosteric Akt inhibitor, acting on Akt1 (IC50: 4.8 nM), Akt2 (IC50: 1.6 nM) and Akt3 (IC50: 44 nM). TAS-117 hydrochloride stimulates anti-myeloma activity, enhances lethal endoplasmic reticulum stress induced by proteasome inhibition, and can induce apoptosis and autophagy.
价 格：￥电议型 号：T62907产 地：中国大陆
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T62905GLS-1-IN-1；化合物 GLS-1-IN-1GLS-1-IN-1
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.
价 格：￥电议型 号：T62905产 地：中国大陆
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T62774BS-181 dihydrochloride；化合物 BS-181 dihydrochlorideBS-181 dihydrochloride
BS-181 dihydrochloride is a selective and potent inhibitor of CDK7 with an IC50 value of 21 nM. BS-181 dihydrochloride inhibits CDK2 (IC50: 880 nM), CDK5 (IC50: 3000 nM) and CDK9 (IC50: 4200 nM), but does not block CDK1, 4 and 6. BS-181 dihydrochloride inhibits the growth of a group of cancer cells (IC50: 11.5 μM-37.3 μM) and induces apoptosis.
价 格：￥电议型 号：T62774产 地：中国大陆
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T62585NAS-181；化合物 NAS-181NAS-181
NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM).NAS-181 enhances the accumulation of 5-HTP in rat brain regions.
价 格：￥电议型 号：T62585产 地：中国大陆
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T62474JS1310；化合物 JS1310PRMT7-IN-1|||JS-1310；PRMT7-IN-1|||JS-1310
JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.
价 格：￥电议型 号：T62474产 地：中国大陆
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T6247Onvansertib；化合物NMS-P937NMS-P937|||NMS-1286937；NMS-P937|||NMS-1286937
Onvansertib (NMS-1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.
价 格：￥电议型 号：T6247产 地：中国大陆
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T62160AS-136A；化合物 AS-136AAS-136A
AS-136A is an orally active, non-nucleoside inhibitor of measles virus RNA-dependent RNA polymerase (RdRp) that acts against measles virus (IC50: 2 μM).
价 格：￥电议型 号：T62160产 地：中国大陆
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T61718mPGES-1-IN-1；化合物 mPGES-1-IN-1mPGES-1-IN-1
MPGES-1, a promising therapeutic target for the next generation of anti-inflammatory drugs in treating inflammatory diseases, possesses an IC50 value of 0.03 μM for mPGES-1-IN-1.
价 格：￥电议型 号：T61718产 地：中国大陆
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T61709AMS-17；化合物 AMS-17AMS-17
AMS-17 is a potent NLRP3 inhibitor, which effectively suppresses microglia activation both in vitro and in vivo. Additionally, AMS-17 exhibits inhibitory effects on various cytokines, such as caspase-1, TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS), in N9 cells. Given these properties, AMS-17 holds promise as a valuable tool for investigating inflammation-associated neurological disorders [1].
价 格：￥电议型 号：T61709产 地：中国大陆
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T6162BS-181 hydrochloride；化合物BS-181 HClBS-181 HCl；BS-181 HCl
BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.
价 格：￥电议型 号：T6162产 地：中国大陆
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T60386LCS-1；化合物 LCS-1LCS-1
LCS-1, a superoxide dismutase 1 (SOD1) inhibitor, effectively inhibits the enzymatic activity of SOD1 with an IC50 value of 1.07 μM. Additionally, LCS-1 triggers both early and late-stage apoptosis in multiple myeloma (MM.1S) cells [1] [2] [3].
价 格：￥电议型 号：T60386产 地：中国大陆
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T5849JMS-17-2；化合物JMS-17-2JMS-17-2
JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
价 格：￥电议型 号：T5849产 地：中国大陆
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T5697BMS-1166；化合物BMS1166BMS-1166
BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.
价 格：￥电议型 号：T5697产 地：中国大陆
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T5675Almonertinib hydrochloride；盐酸阿美替尼HS-10296 hydrochloride；HS-10296 hydrochloride|||盐酸阿美替尼
Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
价 格：￥电议型 号：T5675产 地：中国大陆
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T5462Almonertinib；阿美替尼HS-10296；HS-10296|||阿美替尼
Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.
价 格：￥电议型 号：T5462产 地：中国大陆
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T5337IACS-010759；化合物IACS-10759IACS-10759|||IACS 10759|||IACS10759；IACS-10759|||IACS 10759|||IACS10759
IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.
价 格：￥电议型 号：T5337产 地：中国大陆
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T4944Nervonic acid神经酸cis-15-Tetracosenoic acid|||神经酸|||Selacholeic acid
Nervonic acid (Selacholeic acid) is a long chain unsaturated fatty acid that is enriched in sphingomyelin. It consists of choline, sphingosine, phosphoric acid, and fatty acid. Nervonic acid may enhance the brain functions and prevent demyelination (Chemical Land21). Research shows that there is negative relationship between nervonic acid and obesity-related risk factors. Demyelination in adrenoleukodystrophy (ALD) is associated with an accumulation of very long chain saturated fatty acids stemm
价 格：￥电议型 号：T4944产 地：中国大陆
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T4867Erucic acid；芥酸Prifac 2990|||13(Z)-Docosenoic Acid|||cis-13-docosenoic acid；Prifac 2990|||芥酸|||13(Z)-
Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid (13(Z)-Docosenoic Acid) is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase, which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this, babies should not be given foods high in erucic acid.
价 格：￥电议型 号：T4867产 地：中国大陆
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T4763trans-Cyclohexane-1,2-diol反式-1,2-环己二醇trans-1,2-Cyclohexanediol|||反式-1,2-环己二醇
trans-Cyclohexane-1,2-diol (trans-1,2-Cyclohexanediol) has a synergistic retardation effect on percutaneous absorption and penetration of metronidazole (MTZ).
价 格：￥电议型 号：T4763产 地：中国大陆
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T4485Lazertinib；化合物LazertinibLazertinib (YH25448)|||GNS-1480|||YH25448；Lazertinib (YH25448)|||GNS-1480|||
Lazertinib (GNS-1480) is an effective, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively.
价 格：￥电议型 号：T4485产 地：中国大陆
