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  • T837605-FAM-LL-37 (human) TFA；化合物 5-FAM-LL-37 (human) TFA5-Carboxyfluorescein LL-37；5-Carboxyfluorescein L

    5-FAM-LL-37 is a fluorescently labeled antimicrobial peptide conjugated to 5-carboxyfluorescein (5-FAM) through a 6-aminohexanoic acid (Ahx) linker, featuring excitation/emission maxima at 492/518 nm, respectively. This compound integrates the functional attributes of LL-37 with the fluorescent properties of 5-FAM for enhanced visualization.

    价 格：￥电议型 号：T83760产 地：中国大陆

  • T83759MMP-3 Fluorogenic Substrate TFA；化合物 MMP-3 Fluorogenic Substrate TFAMca-RPKPVE-Nval-WR-K(Dnp)-NH2|||M

    MMP-3 Fluorogenic Substrate, a compound designed for matrix metalloproteinase-3 (MMP-3) activity quantification, releases 7-methoxycoumarin-4-acetyl (Mca) upon MMP-3 cleavage. Mca´s fluorescence, with excitation and emission maxima at 328 and 420 nm respectively, serves as a measurable indicator of MMP-3 activity.

    价 格：￥电议型 号：T83759产 地：中国大陆

  • T83758SAAP 148 TFA；化合物 SAAP 148 TFASynthetic Antimicrobial and Antibiofilm Peptide 148；Synthetic Antimicro

    SAAP 148, an antimicrobial peptide, effectively combats various multidrug-resistant bacteria in vitro and, in vivo, reduces skin colony-forming units (CFUs) in mouse models of A. baumannii or methicillin-resistant S. aureus (MRSA) infections at concentrations ranging from 0.125-2% w/w.

    价 格：￥电议型 号：T83758产 地：中国大陆

  • T83757RG33 TFA；化合物 RG33 TFARG33 TFA

    RG33, a synthetic 33-amino acid peptide, matches the sequence of amino acids 209-219 and 220-241 found in the C-terminal domain class Y helices of apolipoprotein A1 (ApoA1). This compound has the ability to solubilize multilamellar vesicles (MLVs) containing 1,2-dimyristoyl-sn-glycero-3-PC (DMPC), resulting in the formation of recombinant HDL. When bound to lipids, RG33 facilitates cholesterol efflux in J774 macrophages and has been shown to reduce blood glucose levels in insulin-resistant mice

    价 格：￥电议型 号：T83757产 地：中国大陆

  • T83756S1H TFA；化合物 S1H TFASite 1-binding Helix；Site 1-binding Helix

    S1H, a synthetic peptide mimetic of human growth hormone amino acids 36-51, acts as an antagonist to the growth hormone receptor. It forms an α-helical structure in solution and inhibits STAT5 phosphorylation triggered by human growth hormone in SK-MEL-28 and MALME-3M melanoma cell lines, as well as prolactin in IM-9 B cell lymphocytes, at concentrations of 100 and 200 nM.

    价 格：￥电议型 号：T83756产 地：中国大陆

  • T83755ssK36 TFA；化合物 ssK36 TFAssK36 TFA

    ssK36, a peptide super-substrate for the histone methyltransferase SET domain-containing protein 2 (SETD2), is derived from histone H3 lysine 36 (H3K36) amino acids 29-43, with modifications at positions 31, 32, 36, 37, and 39. It undergoes methylation at a rate 70 times greater and 290 times faster than the unmodified H3K36 (29-43) in cell-free assays.

    价 格：￥电议型 号：T83755产 地：中国大陆

  • T83754PKCδ Substrate TFA；化合物 PKCδ Substrate TFAProtein Kinase Cδ Substrate；Protein Kinase Cδ Substrate

    PKCδ substrate, a peptide substrate for PKCδ, facilitates the monitoring of PKCδ activity in both cell-free and cell-based assays.

    价 格：￥电议型 号：T83754产 地：中国大陆

  • T83753RAD17-derived Peptide TFA；化合物 RAD17-derived Peptide TFARAD17-derived Peptide TFA

    RAD17-derived peptide, a substrate for the ataxia-telangiectasia and RAD3-related protein/kinase (ATR), facilitates the identification of ATR inhibitors.

    价 格：￥电议型 号：T83753产 地：中国大陆

  • T83752Biotin-SRC-1 (676–700) TFA；化合物 Biotin-SRC-1 (676–700) TFABiotin-Steroid Receptor Coactivator 1 (676-

    Biotin-SRC-1 (676–700), a biotinylated and truncated variant of steroid receptor coactivator 1 (SRC-1), finds application in affinity-based reporter assays such as time-resolved FRET (TR-FRET) and amplified luminescent proximity homogenous assay (ΑLPHASCREEN?).

    价 格：￥电议型 号：T83752产 地：中国大陆

  • T83751PUMA BH3 (human) TFA；化合物 PUMA BH3 (human) TFAPUMA BH3 (human) TFA

    PUMA BH3, a peptide that includes the BH3 domain from the p53-upregulated modulator of apoptosis (PUMA) and activates the pro-apoptotic protein Bak, demonstrates binding affinity to Bak with dissociation constants (Kds) of 290 nM in HEPES buffer and 26 nM in CHAPS buffer. This interaction with Bak induces its homo-oligomerization and facilitates Bak-mediated membrane permeabilization.

    价 格：￥电议型 号：T83751产 地：中国大陆

  • T83750Melittin (C-Term Cysteine labeled) TFA；化合物 Melittin (C-Term Cysteine labeled) TFAMel-Cys；Mel-Cys

    Melittin (C-term cysteine labeled), a variant of the toxic bee venom peptide melittin featuring a cysteine residue at its C-terminus, effectively induces hemolysis in isolated human red blood cells at both endosomal and extracellular pH levels, with EC50 values of 5 ?M at pH 5.5 and 6 ?M at pH 7.4. This compound is utilized in creating membrane-lytic polymers for the synthesis of polyplexes, facilitating plasmid delivery both in vitro and in vivo.

    价 格：￥电议型 号：T83750产 地：中国大陆

  • T83749Tertiapin LQ TFA；化合物 Tertiapin LQ TFATPNLQ；TPNLQ

    Tertiapin LQ, a peptide derivative of honeybee venom peptide tertiapin, acts as an inhibitor of inwardly rectifying potassium (Kir) channels. Specifically, it targets and inhibits heteromultimeric potassium channels, including those formed by GIRK1 (also known as Kir3.1) and GIRK4 (Kir3.4), as well as inward-rectifier potassium channel 1 (Kir1.1). Its efficaciousness extends to in vivo applications, where it has been observed to suppress the Purkinje cell pause response to conditional stimuli in

    价 格：￥电议型 号：T83749产 地：中国大陆

  • T83748RW4 TFA；化合物 RW4 TFA(RW)4-NH2|||Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2；(RW)4-NH2|||Arg-Trp-Arg-Trp-Arg-T

    RW4, an antimicrobial peptide, exhibits activity against E. coli and S. aureus, with IC50 values of 9.6 and 5.1 ?M, respectively. Additionally, it induces hemolysis of isolated ovine erythrocytes.

    价 格：￥电议型 号：T83748产 地：中国大陆

  • T83747RW3 TFA；化合物 RW3 TFA(RW)3-NH2|||Arg-Trp-Arg-Trp-Arg-Trp-NH2；(RW)3-NH2|||Arg-Trp-Arg-Trp-Arg-Trp-NH2

    RW3, an antimicrobial peptide, exhibits activity against E. coli and S. aureus with IC50 values of 16 ?M and 8 ?M, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes.

    价 格：￥电议型 号：T83747产 地：中国大陆

  • T83746RW2 TFA；化合物 RW2 TFA(RW)2-NH2|||Arg-Trp-Arg-Trp-NH2；(RW)2-NH2|||Arg-Trp-Arg-Trp-NH2

    RW2, an antimicrobial peptide, demonstrates activity against E. coli and S. aureus, with IC50 values of 730 ?M and 210 ?M, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes.

    价 格：￥电议型 号：T83746产 地：中国大陆

  • T83745RYTVELA TFA；化合物 RYTVELA TFAH-Arg-Tyr-Thr-Val-Glu-Leu-Ala-OH；H-Arg-Tyr-Thr-Val-Glu-Leu-Ala-OH

    RYTVELA is a derivative of the peptide antagonist rytvela, targeting interleukin-1 receptor 1 (IL-1R1), and is comprised entirely of L-amino acids.

    价 格：￥电议型 号：T83745产 地：中国大陆

  • T83744Tiger17 TFA；化合物 Tiger17 TFAH-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2；H-Trp-Cys-Lys-Pro-Lys-P

    Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2—antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions—enhances HaCaT keratinocytes and human skin fibroblasts proliferation at 5 to 20 ?g/ml concentrations, and promotes HaCaT cell migration at 20 ?g/ml. Additionally, Tiger17 augments RAW 264.7 macrophages´ recruitment and secretion of TGF-β1 and IL-6. When topically applied at 20 ?g/ml, it accelerates wound closure and re-epithelialization i

    价 格：￥电议型 号：T83744产 地：中国大陆

  • T83743VPM-p15 TFA；化合物 VPM-p15 TFAT1V/F3Phe(4-Me)；T1V/F3Phe(4-Me)

    VPM-p15, a synthetic peptide agonist targeting the adhesion G protein-coupled receptor (GPCR) G2 (ADGRG2)—an orphan GPCR implicated in male infertility—facilitates cAMP accumulation in HEK293 cells expressing human ADGRG2, demonstrating efficacy with an EC50 value of 1.41 ?M.

    价 格：￥电议型 号：T83743产 地：中国大陆

  • T83742SBP1 TFA；化合物 SBP1 TFASpike Binding Peptide 1；Spike Binding Peptide 1

    Spike Binding Peptide 1 (SBP1), representing amino acids 21-43 of angiotensin-converting enzyme 2 (ACE2), has been utilized in a novel approach involving lipid nanoparticles (LNPs) encapsulated with oseltamivir phosphate and conjugated to SBP1. This formulation aims to investigate the possibility of achieving a controlled, long-term in vivo release of oseltamivir phosphate. Furthermore, a 2% concentration of SBP1 immobilized on crosslinked networks composed of hydroxy acrylate and ethylxanthate

    价 格：￥电议型 号：T83742产 地：中国大陆

  • T83741S7 TFA；化合物 S7 TFALeu-Ser-Leu-Iso-Thr-Arg-Leu-OH；Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH

    S7, a peptide antagonist of the IL-6 receptor, concentration-dependently inhibits IL-6 binding to its receptor. At 50 ?M, S7 suppresses IL-6-triggered elevations in VEGF levels within C-33 A cervical cancer cells and RPMI-8226 B cell lymphocytes. It significantly reduces tumor volume in a C-33 A cervical cancer mouse xenograft model with IL-6 overexpression, following a dosage regimen of 50 mg/kg bi-daily. Moreover, when linked to cysteine on lipid nanoparticles (LNPs) encapsulating doxorubicin,

    价 格：￥电议型 号：T83741产 地：中国大陆

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