技术指标

• 应用

  Functional Studies

  Sandwich ELISA

  HPLC

  SDS-PAGE

• 形式

  Lyophilised

• 补充说明

  Lots prior to June 2015 contain 0.036% Tris (including lots GR157466-11, -12 ａnd -13).

• 浓度

  • 由溶解方法决定

  
   

制备和贮存

• 别名

  • APC1
  • APC1 protein
  • Cachectin

• 
  
  
  功能

  Cytokine that binds to TNFRSF1A/TNFR1 ａnd TNFRSF1B/TNFBR. It is mainly secreted by macrophages ａnd can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion ａnd is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation ａnd induce cell differentiation.

• 疾病相关

  Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, ａnd feet; arthritis mutilans, which is a rare but deforming ａnd destructive condition; arthritis of the sacroiliac joints ａnd spine (psoriatic spondylitis).

• 序列相似性

  Belongs to the tumor necrosis factor family.