RS2000系列生物学X-ray辐照仪，可以直接取代传统铯和钴源同位素辐照仪。在剂量均一性、安全性、稳定性、试验重复性等方面更为优秀，已成为生命科学研究领域中的重要科研工具！目前，欧美各国的生物医学科研机构已较少选择同位素辐照仪，而绿色环保、剂量均匀性更佳的Rad Source公司细胞与动物X-ray辐照仪已成为科研领域；

RS2000系列生物学X-ray辐照仪，拥有众多新高科技：反射样品室、高安全性屏蔽技术、射线束过滤技术、杂射线滤出装置、简化易操作触控技术、业内的剂量均一性，剂量均一性约为±2.5%，业内仅有的一款≥95%；剂量率可调:0.1~16Gy/min（=10~1600rad/min =10~1600cGy/min）；

创新--Patented* RAD+ chamber --* Patent No; 6,389,099

Rad Source uses validations from NIST to validate their equipment. In the case of our laboratory irradiators (RS 2000) the AAPM guide to laboratory calibration is used. In either case output from Rad Source irradiators is calibrated to international standards insuring its performance anywhere in the world；

RAD SOURCE为生物学X射线辐照仪领域世界领导品牌，著名科研机构产品，RAD SOURCE被认为是高精密、辐照技术及高质量的代表，性能稳定，拥有的市场份额与科研用户的好评。

RAD SOURCE RS2000系列产品不但成为了美国本土科研机构的，也得到了世界多国高水平科研机构的广泛认可，如：德国、法国、英国、瑞士、意大利、日本、新加坡等；在全球300多家著名研究机构和生物制药研发企业中运转，其性能和品质得到了全球市场的充分验证；辐照仪从2009年起正式供应中国科研机构，已被30多家科研平台所选用，性能和品质也得到了国内用户的广泛认可。

RS2000系列生物学X-ray辐照仪，广泛应用于以下各研究领域

饲养层细胞

干细胞

骨髓移植

肿瘤学

免疫学

DNA损伤相关

信号转导

基因组学

放射生物学

小动物辐照

药物研发

等生物医学领域

Welcome to RAD Source

Since 1997 Rad Source Technologies has been the expert in providing renewable, non-isotope, ionizing radiation replacements for self-shielded gamma irradiators. Currently, there are over 300 renowned hospital, university, and pharmaceutical research institutions using Rad Source X-ray technology. To find out more about our equipment, select your application and you will find equipment specifications, literature references, white papers, training videos, discussion forums, as well as other helpful info；

REASONS WHY THE

RAD SOURCE RS 2000 X-RAY IRRADIATOR

IS THE SYSTEM OF CHOICE FOR YOUR

RESEARCH AND BIOLOGICAL IRRADIATION REQUIREMENTS

The RS 2000 is a research & biological irradiator that features the following advantages:

The RS 2000 is self-contained and requires no external cooling system

NO Nuclear Site license or secure/shielded room is needed

The RS 2000 is ideal for small animal research when using our patented RAD + reflective cage enclosure. This unique and patented feature provides for a dose rate within the cage of 1.2 Gy/min (120 rads/min or the same as gamma irradiator) and the dose distribution is better than 94% across the entire field (much better than a gamma irradiator). The RAD+ is designed to hold one standard Allentown filtered rearing cage. (Three of which are supplies with the system.) This feature improves animal husbandry by allowing transport and irradiation of the animals inside a filtered environment mitigating cross-contamination issues. Because the animals are irradiated in their cage, multiple mice can be irradiated during one cycle. IF itis important for you to have reproducible results that equate to theirradiation standard of Cesium - the only choice is the RS 2000 with .3mm of Copper filter irradiating at 160 kV AT 25 mA (NEW 225 kV available).

The RS 2000 is ideal for targeted tumor irradiation using our spot beam collimator or custom animal shielding and offers variable dose rates to the target.

For Cells and other research the RS 2000 has dose rates of >5 Gy/min (500 rads/min.) filtered and up to >17 Gy/min unfiltered.

This is the only system available that allows for 160 kV operation @ 25 mA (not “AND or OR” but AT 25 mA)

“Plug and Play” installation: Installation, dose-mapping & in-service in one day.

Mounted on wheels

Footprint 33” X 42” (82.8 cm X 106.7 cm) and weighs 1250 lbs (567 kg).

Simple touch screen operators’ panel for ease of use and operation.

Please review the information on our website: www.radsource.com

Rad Source is the recognized expert in the field of x-ray irradiation. We developed the only US-FDA approved blood irradiator for replacing Cs irradiators and are the leaders in high dose, high volume irradiation systems worldwide

The RS 2000 should be the choice for your next

professional quality biological and research irradiator

Features

   ·      “Plug and Play” Installation

   ·      Unit is mounted on caster wheels for easy movement

   ·      Self-contained cooling

   ·      Easy access to built-in calibration port

   ·      Specialized filtration eliminates lower energy X-rays

   ·      Optimal for split-dose delivery

   ·      Easy to use touch screen operation

   ·      CE Marked & Compliant

   ·      Renewable Ionizing Radiation

   ·      No NRC License Required

   ·      No shielded or secure room required

   ·      No disposal costs

部分科研机构文献

      RAD SOURCE RS2000系列产品得到了广泛应用，文献发表在以下期刊：Cancer Res.、BLOOD、PANS、CELL、Stem Cell Biology、JEM、Nature、The Journal of Immunology、Hematology and Stem Cells、Stem Cells、PLoS Biology、Liver、I Int. J. Biol. Sci.、THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS、MOLECULAR AND CELLULAR BIOLOGY、Experimental Hematology等。

1、DNA damage checkpoint control in cells exposed to ionizing radiation

NATURE

George Iliakis*,1, Ya Wang2, Jun Guan2 and Huichen Wang2

1Institute of Medical Radiation Biology, University of Essen Medical School, Hufelanstrasse 55, 45122 Essen, Germany; 2Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA

2、Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

CELL

Centre de recherche CHU Ste-Justine, Montre′ al, QC, Canada； 2Lawrence Berkeley National Laboratory, Berkeley, CA, USA

3Buck Institute for Age Research, Novato, CA, USA；4Department of Biochemistry and Molecular Genetics, University of Colorado Denver, School of Medicine, Aurora, CO, USA

3、Nuclear Localization of p38 MAPK in Response to DNA Damage

I Int. J. Biol. Sci. 2009, 5

C. David Wood1, Tina M. Thornton1, Guadalupe Sabio2, Roger A. Davis2,

1. Department of Medicine/Immunobiology Program, University of Vermont, Burlington,   VT 05405. USA.

2. Program in Molecular Medicine, University of Massachusetts, Worcester, MA 01605.Correspondence to: Mercedes Rincon

Received: 2009.04.30; Accepted: 2009.06.10; Published: 2009.06.16

4、Passive and Active Mechanisms Trap Activated CD8+ T Cells in the ...

The Journal of Immunology

Six- to 8-wk-old mice were irradiated with 1000 rad (10 Gy) as a single dose from an RS2000

x-ray irradiator (Rad Source; Rad Source Technologies, Coral Springs, FL) and used as recipients.

Mature T cells were depleted from donor bone ...

www.jimmunol.org/cgilcontent/full/172/9/5222

5、Expression of common chromosomal fragile site genes, VVWOX/FRA 16D ..

MOLECULAR CARCINOGENESIS

fluency were irradiated in RS2000 X-ray Irradiator. (Rad Source Technologies, Inc., Boca Raton, FL). Control cells were sham-irradiated in both the UV-. C and ionizing radiation (IR) experiments. For BPDE. treatment,8t-dihydroxy-9 ... doLwiley.com

6、Complete differentiation of CD8+ T cells activated locally within ...   

JEM

6 8-wk-old recipient mice were irradiated with a dose of 10 Gy (1000 rad) using an RS2000 X-ray irradiator (RadSource Technologies). Depletion of mature T lymphocytes from donor bone marrow cells was achieved by incubation with anti-CD4 ...

7、An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells

BLOOD

Monica L. Guzman,1 Randall M. Rossi,1 Sundar Neelakantan,2 Xiaojie Li,1 Cheryl A.

8、Ku86 Modulates DNA Topoisomerase I–Mediated Radiosensitization, but not Cytotoxicity,   in Mammalian Cells

Cancer Res 2005

Shyh-Jen Shih, Tara Erbele, and Allan Y. Chen

Department of Radiation Oncology, University of California Davis Medical Center, Sacramento,California

 9、Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal Inflammation  

PANS

Simona Zarini1, Miguel A. Gijo′ n1, Aaron E. Ransome, Robert C. Murphy2

Department of Pharmacology, University of Colorado Denver, Mail Stop 8303, 12801 East 17th Avenue, Aurora Communicated by K. Frank Austen, Brigham and Women’s Hospital, Boston, MA, April 7, 2009 (received for review February 23, 2009)

10、Irradiation Selects for p53-Deficient Hematopoietic Progenitors

PLoS Biology

Andriy Marusyk1,2¤, Christopher C. Porter1,3, Vadym Zaberezhnyy1 DeGregori1,2,3,4*

Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America, 2 Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America

11、Kupffer cell heterogeneity: functional properties of bone marrow–derived and sessile hepatic

macrophages

BLOOD

Ingo Klein, 1,2 Judith C. Cornejo,3 Noelle K. Polakos,2 Beena John,2 Sherry A.

1David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical

Research, University of Rochester School of Medicine and Dentistry, NY;

Received February 11, 2007; Accepted July 25, 2007.

12、Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors   

Cancer Res 2009

Andriy Marusyk,1,2 Matias Casa′s-Selves,1,2 Curtis J. Henry,1,4 Vadym Zaberezhnyy,1

Jelena Klawitter,5 Uwe Christians,5 and James DeGregori1,2,3,4

1Department of Biochemistry and Molecular Genetics, 2Program in Molecular Biology,

3Department of Pediatrics, 4Integrated

Department of Immunology; and 5Department of Anesthesiology, University of Colorado

Denver School of Medicine, Aurora, Colorado

 13、Progression of Pancreatic Adenocarcinoma Is Significantly Impeded with a Combination of

   Vaccine and COX-2 Inhibition1

The Journal of Immunology

Pinku Mukherjee,2* Gargi D. Basu,? Teresa L. Tinder,* Durai B. Subramani,*

Judy M. Bradley,* Million Arefayene,? Todd Skaar,? and Giovanni De Petris§