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技术文章
FGF-1/ FGFa/ FGF-acidic (Ala2-Asp155), Human, Recombinant
点击次数：177 发布时间：2020/12/25 11:19:22
别名 Fibroblast Growth Factor 1; FGF-1; Acidic Fibroblast Growth Factor; aFGF; Endothelial Cell Growth Factor; ECGF H
Binding Growth Factor 1; HBGF-1; FGF1; FGFA
物种 Human
表达宿主 E.coli
序列信息 Ala2-Asp155
检索号 P05230
分子量 17.3 kDa
表观分子量 17 kDa
生物活性 Testing in progress
产品特性
纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted
solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 month
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed bel
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复融 Please refer to it for detailed information.
背景介绍
FGF acidic, also known as ECGF, FGF-1and HBGF-1, is a non-glycosylated heparin binding Growth Factor that is expressed in the b
kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes ａnd endothelial cells. It is a mitogenic peptide that is pro
by multiple cell types ａnd stimulates the proliferation of cells of mesodermal, ectodermal, ａnd endodermal origin. Its association
heparan sulfate is a prerequisite for activation of FGF Receptors. Internalized FGF acidic migrates to the nucleus where it is
phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, ａnd degraded. Intracellular FGF acidic inhibits p
activity ａnd proapoptotic signaling.
原创作者：上海圻明生物科技有限公司
