英文名：DOTA-c(RGDfK)，

DOTA-cyclo(RGDfK）

CAS：N/A

所属分类：Bifunctional chelato

一、Product parameters：

1.Molecular formula：C43H67N13O14

2.Molecular weight：989.09

3.Packaging specification：1g、5g、10g, flexible packaging, including 100mg packaging ａnd 500mg 1g ａnd 5g large packaging

Product structure：

二、Reaction characteristics：

DOTA-cyclo(RGDfK)螯合剂多肽，RGD肽是指含有由Arg-Gly-Asp三个氨基酸组成的序列多肽，有直线肽和环肽之分。它们是许多细胞外基质蛋白（如VN、FN、FGN、胶原等）等小识别短肽序列。RGD作为某些整合素的受体，其选择性部分依赖于RGD的构象以及RGD周围的氨基酸残基。DOTA 中的四个氮原子和以及氮原子上乙酸中的羧基可与金属配位，是一类常用的双功能螯合剂。

DOTA cycle (RGDfK) chelating agent peptide, RGD peptide refers to a sequence peptide composed of Arg Gly Asp three amino acids, which can be divided into linear peptide ａnd cyclic peptide. They are small recognition short peptide sequences of many extracellular matrix proteins (such as VN, FN, FGN, collagen, etc.). As a receptor for certain integrins, the selectivity of RGD partially depends on the conformation of RGD ａnd the amino acid residues around RGD.

三、Matters for use：

It is sensitive to light ａnd temperature. In order to use the reagent effectively, the material should always be kept in a low temperature dry condition, away from light, ａnd avoid frequent thawing ａnd freezing.

四、storage conditions:

Store at - 20 ℃ as much as possible. If conditions permit, the material can be treated under inert gas to obtain better stability of the reagent.

相关试剂：

Cyclo(-Hyp-Gly)

CTTHWGFTLC, CYCLIC

(R)-tert-Bu4-DOTAGA

FAPI-4-NH2

DOTA-E-[cyclo(RGDfK(Acp))]2

cyclo(RGDFK(DOTA)）

DOTA-cyclo(RGDfK) acetate

DOTA-cyclo(RGDyK)

DOTA-E[c(RGDfK)2]

DOTA-cyclo(RGDfK)

DOTA-E[c(RGDyK)2]

Exendin-4

DOTA-DBCO

DOTA-PEG5-DBCO

DOTA-PEG5-azide

Fmoc-Thr(Ac3GalNAcα)-OH

Fmoc-Thr(Ac4Galβ1-3Ac2GalNAcα)-OH

Fmoc-Thr(Me,Ac4Neu5Acα2-6Ac2GalNAcα)-OH

Fmoc-Thr(Ac4Manα)-OH

Fmoc-Thr(Ac4Manα1-2Ac3Manα)-OH

Fmoc-Thr((Ac4Galβ1-3)Ac3GlcNAcβ1-6AcGalNAcα)-OH

Fmoc-Thr(Ac4Manα1-2Ac3Manα1-2Ac3Manα)-OH

Fmoc-L-Thr(Ac4-D-Glcβ)-OH

Fmoc-D-Thr(Ac4-L-Manα)-OH

3,4,6-Tri-O-acetyl-D-galactal

D-Galacyranose pentaacetate