中文名:环(L-精氨酰甘氨酰-L-Α-天冬氨酰-D-酪氨酰-L-赖氨酰)
英文名:Cyclo(-Arg-Gly-Asp-D-Tyr-Lys)
cyclo(RGD-DTyr-K)
CYCLO(-ARG-GLY-ASP-D-TYR-LYS)
c(RGDyK)
CAS:217099-14-4
等电点(PI):10.46
平均亲水性:1.675
pH=7.0时的净电荷数:1.98
疏水性值:-2.72
密度: 1.52±0.1 g/cm3(Predicted)
溶解度: Soluble in DMSO
储存条件: Store at -20°C
酸度系数(pKa): 4.01±0.10(Predicted)
性状:白色粉末状固体
Molecular formula:C27H41N9O8
Molecular weight:619.67
Purity:95%+
Appearance:solid/powder
Matters for use:
It is sensitive to light and temperature. In order to use the reagent effectively, the material should always be kept in a low temperature dry condition, away from light, and avoid frequent thawing and freezing.
storage conditions:
Store at - 20 ℃ as much as possible. If conditions permit, the material can be treated under inert gas to obtain better stability of the reagent.
Packing specification:1g,5g,10g
Supplier:陕西新研博美生物科技有限公司
结构式:
产品介绍:
Cyclo(-Arg-Gly-Asp-D-Tyr-Lys)属于多肽试剂,RGD肽是指含有由Arg-Gly-Asp三个氨基酸组成的序列多肽,有直线肽和环肽之分。它们是许多细胞外基质蛋白(如VN、FN、FGN、胶原等)等小识别短肽序列。根据肽链的构成可将多肽分为同聚肽(Homomeric)和杂聚肽(Heteromeric)两大类,者完全由氨基酸组成,后者是由氨基酸部分和非氨基酸部分组成的,如糖肽。
Cyclo(RGDyK) 是一种有效的选择性 αVβ3 整联蛋白 (integrin) 抑制剂,IC50 为 20 nM。
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