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徕卡抗体Anaplastic Lymphoma Kinase
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产品摘要：Anaplastic large cell lymphoma (ALCL) is usually composed of largepleomorphic cells which are reported to express CD30 antigen and theepithelial membrane antigen (EMA).
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详细内容
徕卡抗体Anaplastic Lymphoma Kinase
Clone 5A4
7 mL BOND ready-to-use PA0306 P (HIER)
Antigen Background
Anaplastic large cell lymphoma (ALCL) is usually composed of large
pleomorphic cells which are reported to express CD30 antigen ａnd the
epithelial membrane antigen (EMA). These tumor cells tend to occur in
younger individuals ａnd may be associated with cutaneous ａnd extranodal
involvement. A proportion of these cases contain a chromosomal
translocation t(2;5) (p23; q35). This results in a hybrid gene encoding part of
the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the
anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large
cell lymphomas account for approximately 25 percent of all non-Hodgkin＇s
lymphomas in children ａnd young adults, of which one third carries the NPMALK gene translocation.
Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma
kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin
section.
Clone 5A4
7 mL BOND ready-to-use PA0306 P (HIER)
Antigen Background
Anaplastic large cell lymphoma (ALCL) is usually composed of large
pleomorphic cells which are reported to express CD30 antigen ａnd the
epithelial membrane antigen (EMA). These tumor cells tend to occur in
younger individuals ａnd may be associated with cutaneous ａnd extranodal
involvement. A proportion of these cases contain a chromosomal
translocation t(2;5) (p23; q35). This results in a hybrid gene encoding part of
the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the
anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large
cell lymphomas account for approximately 25 percent of all non-Hodgkin＇s
lymphomas in children ａnd young adults, of which one third carries the NPMALK gene translocation.
Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma
kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin
section.
热门标签：ALCL 克隆抗体 Anaplastic Lymphoma Kinase
