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徕卡Bcl-2 Oncoprotein蛋白抗体
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产品摘要：Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a widetissue distribution. It is considered to act as an inhibitor of apoptosis.
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详细内容
徕卡Bcl-2 Oncoprotein蛋白抗体
Clone bcl-2/100/D5
7 mL BOND ready-to-use PA0117 P (HIER)
Antigen Background
Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2
is an integral inner mitochondrial membrane protein of 25 kD ａnd has a wide
tissue distribution. It is considered to act as an inhibitor of apoptosis. For this
reason, bcl-2 expression is inhibited in germinal centers where apoptosis
forms part of the B cell production pathway. In 90 percent of follicular
lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21,
to an immunoglobulin gene. This t(14;18) translocation can deregulate gene
expression ａnd bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.
Also available as a liquid concentrate, refer to page 98
Human diffuse large B cell lymphoma: immunohistochemical staining for Bcl-6 using PA0204.
Note nuclear staining of neoplastic cells. Paraffin section.
Clone bcl-2/100/D5
7 mL BOND ready-to-use PA0117 P (HIER)
Antigen Background
Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2
is an integral inner mitochondrial membrane protein of 25 kD ａnd has a wide
tissue distribution. It is considered to act as an inhibitor of apoptosis. For this
reason, bcl-2 expression is inhibited in germinal centers where apoptosis
forms part of the B cell production pathway. In 90 percent of follicular
lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21,
to an immunoglobulin gene. This t(14;18) translocation can deregulate gene
expression ａnd bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.
Also available as a liquid concentrate, refer to page 98
Human diffuse large B cell lymphoma: immunohistochemical staining for Bcl-6 using PA0204.
Note nuclear staining of neoplastic cells. Paraffin section.
