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Calcitonin多克隆抗体
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产品摘要：Calcitonin (CT) is a 32 amino acid peptide synthesized by the parafollicular Ccells of the thyroid.
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详细内容
Calcitonin多克隆抗体
Polyclonal
7 mL BOND ready-to-use PA0406 P (Enzyme)
Antigen Background
Calcitonin (CT) is a 32 amino acid peptide synthesized by the parafollicular C
cells of the thyroid. It acts through its receptors to inhibit osteoclast mediated
bone resorption, decrease calcium resorption by the kidney ａnd decrease
calcium absorption by the intestines. The action of calcitonin is therefore to
cause a reduction in serum calcium, an effect opposite to that of parathyroid
hormone. The calcitonin gene transcript also encodes the calcitonin generelated peptide (CGRP), which is thought to be a potent vasodilator. The tissue specificity of the transcript produced depends on alternative splicing of the
CT/CGRP gene transcript. In the parafollicular cells of the thyroid 95 percent
of the CT/CGRP is processed ａnd translated to produce CT, however, in
neuronal cells 99 percent of the CT/CGRP RNA is translated into CGRP. The C
cells of the thyroid give rise to an endocrine tumor, medullary thyroid
carcinoma (MTC), which occurs in a sporadic (75 percent of cases) and
hereditary form (25 percent of cases). Familial MTC is associated with C cell
hyperplasia (CCH), whereas sporadic MTC is thought not to be. However, in
the general population CCH is present in 20-30 percent of thyroid glands,
either with normal histology, thyroiditis or follicular tumors.
Medullary carcinoma: immunohistochemical staining with BOND ready-to-use Calcitonin
(Polyclonal) using BOND Polymer Refine Detection.
Polyclonal
7 mL BOND ready-to-use PA0406 P (Enzyme)
Antigen Background
Calcitonin (CT) is a 32 amino acid peptide synthesized by the parafollicular C
cells of the thyroid. It acts through its receptors to inhibit osteoclast mediated
bone resorption, decrease calcium resorption by the kidney ａnd decrease
calcium absorption by the intestines. The action of calcitonin is therefore to
cause a reduction in serum calcium, an effect opposite to that of parathyroid
hormone. The calcitonin gene transcript also encodes the calcitonin generelated peptide (CGRP), which is thought to be a potent vasodilator. The tissue specificity of the transcript produced depends on alternative splicing of the
CT/CGRP gene transcript. In the parafollicular cells of the thyroid 95 percent
of the CT/CGRP is processed ａnd translated to produce CT, however, in
neuronal cells 99 percent of the CT/CGRP RNA is translated into CGRP. The C
cells of the thyroid give rise to an endocrine tumor, medullary thyroid
carcinoma (MTC), which occurs in a sporadic (75 percent of cases) and
hereditary form (25 percent of cases). Familial MTC is associated with C cell
hyperplasia (CCH), whereas sporadic MTC is thought not to be. However, in
the general population CCH is present in 20-30 percent of thyroid glands,
either with normal histology, thyroiditis or follicular tumors.
Medullary carcinoma: immunohistochemical staining with BOND ready-to-use Calcitonin
(Polyclonal) using BOND Polymer Refine Detection.
热门标签：多克隆 Polyclonal 徕卡抗体
