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钙结合蛋白Calponin (Basic)抗体
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产品摘要：Calponin (Basic) is an actin, tropomyosin and calmodulin binding proteinthought to be involved in the regulation of smooth muscle contraction.
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详细内容
钙结合蛋白Calponin (Basic)抗体
Clone 26A11
7 mL BOND ready-to-use PA0416 P (HIER)
Antigen Background
Calponin (Basic) is an actin, tropomyosin ａnd calmodulin binding protein
thought to be involved in the regulation of smooth muscle contraction. The
expression of basic calponin is reported to be restricted to smooth muscle
cells ａnd is a marker of the differentiated contractile phenotype of developing
smooth muscle. Vascular smooth muscle cells convert to a synthetic
dedifferentiated phenotype when this protein is lost ａnd this is a key stage in
both atherosclerosis ａnd restenosis of coronary arteries after balloon
angioplasty. It is thought that basic calponin exerts its effect via the cortical
actin cytoskeleton ａnd therefore influences proliferation, the transformed
phenotype ａnd the metastatic potential of tumor cells. Basic calponin mRNA
is expressed in smooth muscle of prostate, bowel ａnd aorta whereas neutral
and acidic calponin mRNAs are expressed in non-smooth muscle tissues
such as heart, placenta, lung, kidney, pancreas, spleen, testis ａnd ovary as
well as in smooth muscle-containing tissues.
Breast carcinoma: immunohistochemical staining with BOND ready-to-use Calponin (Basic)
(26A11) using BOND Polymer Refine Detection.
Clone 26A11
7 mL BOND ready-to-use PA0416 P (HIER)
Antigen Background
Calponin (Basic) is an actin, tropomyosin ａnd calmodulin binding protein
thought to be involved in the regulation of smooth muscle contraction. The
expression of basic calponin is reported to be restricted to smooth muscle
cells ａnd is a marker of the differentiated contractile phenotype of developing
smooth muscle. Vascular smooth muscle cells convert to a synthetic
dedifferentiated phenotype when this protein is lost ａnd this is a key stage in
both atherosclerosis ａnd restenosis of coronary arteries after balloon
angioplasty. It is thought that basic calponin exerts its effect via the cortical
actin cytoskeleton ａnd therefore influences proliferation, the transformed
phenotype ａnd the metastatic potential of tumor cells. Basic calponin mRNA
is expressed in smooth muscle of prostate, bowel ａnd aorta whereas neutral
and acidic calponin mRNAs are expressed in non-smooth muscle tissues
such as heart, placenta, lung, kidney, pancreas, spleen, testis ａnd ovary as
well as in smooth muscle-containing tissues.
Breast carcinoma: immunohistochemical staining with BOND ready-to-use Calponin (Basic)
(26A11) using BOND Polymer Refine Detection.
