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CBP73339 EML4-ALK V1 G1202R/G1269A/L1204V/BaF3

点击次数:4发布时间:2023/4/21 8:39:11

CBP73339  EML4-ALK V1 G1202R/G1269A/L1204V/BaF3

更新日期:2023/4/21 8:39:11

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产品型号:CBP73339

简单介绍:CBP73339I. Introduction Cell Line Name:EML4-ALK V1 [G1202R/G1269A/L1204V]/BaF3Host Cell:Ba/F3Stabili

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详细内容


CBP73339
I. Introduction

Cell Line Name:

EML4-ALK V1 [G1202R/G1269A/L1204V]/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

EML4-ALK results from the fusion of EML4 and ALK, resulting in constitutive kinase activity, transformation in cultured cells, and tumor activity in mouse models (PMID: 19064915, PMID: 17625570). EML4-ALK fusions have been associated with non-small cell lung cancer (PMID: 26755435).

III. Representative Data

1.WB of EML4-ALK V1 [G1202R/G1269A/L1204V]/BaF3


2. Sanger of EML4-ALK V1 [G1202R/G1269A/L1204V]/BaF3

Figure 1. EML4-ALK V1 [G1202R/G1269A/L1204V]/BaF3 Fusion

Figure 2. EML4-ALK V1 [G1202R/G1269A/L1204V]/BaF3 G1202R+L1204V

Figure 3. EML4-ALK V1 [G1202R/G1269A/L1204V]/BaF3 G1269A

3. Anti-proliferation assay

Figure 4. CTG Proliferation Assay of BaF3 EML4-ALK V1 [G1202R/G1269A/L1204V] (C1).



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