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CBP73225 TPM3-NTRK1 G595R/BaF3激酶
点击次数：4发布时间：2023/5/16 13:38:20
更新日期：2023/5/16 13:38:20
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产品型号：CBP73225
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详细内容
| CBP73225 | |
| I. Introduction | |
Cell Line Name： | TPM3-NTRK1 [G595R]/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
Mycoplasma Status: | Negative |
| II.Background | |
TPM3, tropomyosin 3, is a member of the tropomyosin family of actin-interacting proteins, which regulates actin function and plays an essential role in embryonic development (PMID: 23904035, PMID: 26240174). TPM3-NTRK1 fusions are recurrent in colorectal cancer (PMID: 24962792, PMID: 30279230) and additional fusions, with multiple gene partners, have been identified in other tumor types, including inflammatory myofibroblastic tumors (PMID: 10934142), anaplastic large cell lymphoma (PMID: 10216106), renal cell carcinoma (PMID: 32102128), and lung cancer (PMID: 25667280). | |
| III. Representative Data | |
1.TPM3-NTRK1 G595R/BaF3
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2. Anti-proliferation assay | |
Figure . Anti-proliferation assay of three reference compounds on the TPM3-NTRK1 G595R/BaF3 Stable Cell Line. | |
