产品展示
CBP73097 FLT3-ITD D835V/BaF3激酶
点击次数：6发布时间：2023/6/5 14:03:06
更新日期：2023/6/5 14:03:06
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产品型号：CBP73097
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详细内容
| CBP73097 | |
| I. Introduction | |
Cell Line Name： | FLT3-ITD [D835V]/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385). | |
| III. Representative Data | |
1.FLT3-ITD [D835V]/BaF3 | |
2. Anti-proliferation assay | |
Figure . Anti-proliferation assay of two reference compounds on the FLT3-ITD [D835V]/BaF3 Stable Cell Line. | |
