产品展示
CBP73218 EGFR D770_N771insY/BaF3激酶细胞
点击次数：8发布时间：2023/6/23 13:02:34
更新日期：2023/6/23 13:02:34
所 在 地：
产品型号：CBP73218
优质供应
详细内容
| CBP73218 | |
| I. Introduction | |
Cell Line Name： | EGFR D770_N771insY/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
EGFR D770_N771insY results in the insertion of a tyrosine (Y) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insY has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160). | |
| III. Representative Data | |
1. WB of EGFR D770_N771insY/BaF3
| |
| 2. Anti-proliferation assay | |
