产品展示
CBP73334 PDGFRA D842V-G680R/BaF3 Kinase细胞株
点击次数：9发布时间：2023/6/28 17:48:32
更新日期：2023/6/28 17:48:32
所 在 地：
产品型号：CBP73334
优质供应
详细内容
| CBP73334 | |
| I. Introduction | |
Cell Line Name： | PDGFRA D842V-G680R/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
PDGFRA D842V lies within the protein kinase domain of the Pdgfra protein (UniProt.org). D842V results in ligand-independent phosphorylation of Pdgfra, activation of downstream signaling, and is transforming in culture (PMID: 22745105, PMID: 23752188, PMID: 29533785, PMID: 30253204) and confers resistance to PDGFRA inhibitors (PMID: 30389923, PMID: 18955458). | |
| III. Representative Data | |
1.Sanger of PDPDGFRA D842V-G680R/BaF3
Figure 1. PDGFRA D842V-G680R/BaF3 G680R
Figure 2. PDGFRA D842V-G680R/BaF3 D842V | |
2. Anti-proliferation assay | |
Figure 3. CTG Proliferation Assay of BaF3 PDGFRA D842V/G680R Cells (C1). | |
