Cell Line Name：

EGFR V769_D770insASV/BaF3

Host Cell:

Ba/F3

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

Complete Culture Medium:

Mycoplasma Status:

Negative

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR V769_D770insASV results in the insertion of three amino acids in the protein kinase domain of the Egfr protein between amino acids 769 and 770 (UniProt.org). V769_D770insASV has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions.

1.WB of EGFR expression

2. Sanger Sequencing of EGFR V769_D770insASV

3. Anti-proliferation assay

Figure 3 . Anti-proliferation assay of three reference compounds on the EGFR V769_D770insASV/BaF3 Stable Cell Line.