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详细内容
| CBP73183 | |
| I. Introduction | |
Cell Line Name： | EGFR D770>GY/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity.EGFR D770_N771insG results in the insertion of a glycine (G) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insG has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions. | |
| III. Representative Data | |
1. WB of EGFR D770>GY/BaF3
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2. Anti-proliferation assay
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