产品展示
瑞莎珠单抗Risankizumab
点击次数：200发布时间：2023/6/22 16:07:22
更新日期：2024/9/6 9:14:37
所 在 地：中国大陆
产品型号：
优质供应
详细内容
生物活性
Risankizumab (BI 655066) 是一种人源化 IgG 单克隆抗体，靶向 IL-23 p19 亚基(Kd <10 pM)，并能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生(IC50 = 2 pM)。Risankizumab 可用于研究免疫性和炎症性疾病，如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病。
化学性质
| CAS号 | 1612838-76-2 |
| 储存条件 | Please store the product under the recommended conditions in the Certificate of Analysis. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
| 生物活性 | Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (Kd <10 pM) ａnd inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to research immunological ａnd inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis ａnd erythrodermic psoriasis[1][2][3]. | ||||||||
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| 体外研究 (In Vitro) | Risankizumab (BI 655066) has a high affinity for human ａnd cynomolgus IL23 with Kds <10 pM[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 (In Vivo) | Risankizumab (BI 655066) (1 mg/kg; i.p.; single dosage) inhibits IL23-induced mice ear swelling ａnd cytokine production[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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| 性状 | Liquid | ||||||||
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| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
