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γ-氨基丁酸

A2129γ-氨基丁酸

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价格：￥电议

型号：A2129 原产地：中国大陆发布时间：2016/12/21 16:28:55更新时间：2024/11/12 9:28:20

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详细内容

γ-Aminobutyric acid

≥99%

别名: 4-氨基丁酸, GABA, gamma-Aminobutyric acid, 哌啶酸, 氨酪酸

CAS号 56-12-2
线性分子式 NH₂(CH₂)₃COOH
分子量 103.12
Beilstein Registry Number 906818
EINECS 编号 200-258-6
MDL number MFCD00008226

PubChem Substance ID 24278167

性质

Related Categories	Agonists, Amino Acid, Amino acids, Functional Foods, GABA ａnd Glycine Receptor Modulators, GABAergic, GABAergics, GABAergics - GABA-B Agonists, GPCR Modulators, GPCR Proteins, Modulators ａnd Antibodies, Ginkgo biloba, Humulus lupulus (Hops), Hypericum perforatum (St John′s wort), Ion Channels, Ligand-Gated Ion Channels, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmission (Obesity), Neurotransmitters, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb), Zingiber officinale (Ginger), 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 肥胖研究, 营养研究, 蛋白质及衍生物更多...
InChI Key	BTCSSZJGUNDROE-UHFFFAOYSA-N
assay	≥99%
mp	195 °C (dec.)(lit.)
Gene Information	human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SLC6A1(6529), SLC6A11(6538), SLC6A12(6539) rat ... Gabbr1(81657), Gabra1(29705), Gabra2(29706), Gabrb2(25451), Gabrg2(29709), Slc6a1(79212), Slc6a12(50676)

产品描述

Biochem/physiol Actions

大脑中的主要抑制性神经递质；GABA_A 和 GABA_B受体激动剂；增加 Cl⁻ 的传导性。

GABA (γ-Aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the central nervous system ａnd also functions as a neuromodulator in some peripheral tissues. It binds to GABA_A receptor ａnd inhibits the activity of signal-receiving neurons. The GABA_A receptors are found to form a channel in the cell membranes of neurons. Upon binding of GABA, the receptor is activated to allow the passage of negatively charged molecules, such as chloride ions, into the cell. This results in lowering of excitability of the cell.^[4]
GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation, ａnd anaesthetics. GABA can also influence heart rate ａnd blood pressure.^[5]

Application

γ-Aminobutyric acid (GABA) has been used:
• in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for GABA immunostaining^[1]
• in the macromolecule suppressed detection of GABA by magnetic resonance spectroscopy (MRS)^[2]
• in the intraintestinal application of GABA in order to increase intraluminal fluid secretion^[3]

Features ａnd Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC^®¹²⁸⁰), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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γ-氨基丁酸

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