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γ-氨基丁酸
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详细内容
≥99%
别名: 4-氨基丁酸, GABA, gamma-Aminobutyric acid, 哌啶酸, 氨酪酸
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CAS号 56-12-2
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线性分子式 NH2(CH2)3COOH
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分子量 103.12
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Beilstein Registry Number 906818
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EINECS 编号 200-258-6
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MDL number MFCD00008226
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PubChem Substance ID 24278167
性质
Related Categories Agonists, Amino Acid, Amino acids, Functional Foods, GABA and Glycine Receptor Modulators, InChI Key BTCSSZJGUNDROE-UHFFFAOYSA -N assay ≥99% mp 195 °C (dec.)(lit.) Gene Information human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Gabbr1(81657), Gabra1(29705), Gabra2(29706), Gabrb2(25451), Gabrg2(29709), Slc6a1(79212), Slc6a12(50676)产品描述
Biochem/physiol Actions
大脑中的主要抑制性神经递质;GABAA 和 GABAB 受体激动剂;增加 Cl− 的传导性。
GABA (γ-Aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the central nervous system and also functions as a neuromodulator in some peripheral tissues. It binds to GABAA receptor and inhibits the activity of signal-receiving neurons. The GABAA receptors are found to form a channel in the cell membranes of neurons. Upon binding of GABA, the receptor is activated to allow the passage of negatively charged molecules, such as chloride ions, into the cell. This results in lowering of excitability of the cell.[4]
GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation, and anaesthetics. GABA can also influence heart rate and blood pressure.[5]Application
γ-Aminobutyric acid (GABA) has been used:
• in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for GABA immunostaining[1]
• in the macromolecule suppressed detection of GABA by magnetic resonance spectroscopy (MRS)[2]
• in the intraintestinal application of GABA in order to increase intraluminal fluid secretion[3]
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
法律信息
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