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当前位置: 易推广 > 生物试剂/抗体/细胞 > 精细化工 > 化工产品 > 上海恒远生物技术发展有限公司 > 产品展示 > ABCAM抗体 > 一抗 > Rabbit Anti-MYD88

Rabbit Anti-MYD88

价格:¥电议

品牌名称:$brandModel.Title(进口品牌)型号:HZ922131 原产地:其它 发布时间:2018/6/25 11:06:50更新时间:2024/11/25 9:12:31

产品摘要:Rabbit Anti-MYD88 The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-RAcP.

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详细内容

                Rabbit Anti-MYD88
Background: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (Muzio et al. 1997). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (Adachi et al. 1 998; Medzhitov et al. 1998), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-defecient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

specificity :
–Anti- MYD88 is a rabbit polyclonal antibody unconjugated
–specific for MYD88 of human, mouse and rat,chicken
–use for western blotting,elisa,immunoprecipitation and immunohistochemistry
–Protein G affinity chromatography purification, purity :>95%
–Isotype: IgG
–mol wt: 34kDa

Application :
–Western blotting 1:100-500
–Immunohistochemistry 1:100-500
–ELISA 1:500-1000
–Optimal working dilutions must be determined by the end user.
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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