S100B蛋白抗体Anti-S100B/S100 beta的产品详细说明：

－－产品介绍：S100 beta is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, ａnd involved in the regulation of a number of cellular processes such as cell cycle progression ａnd differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC mediated phosphorylation, astrocytosis ａnd axonal proliferation, ａnd inhibition of microtubule assembly. Chromosomal rearrangements ａnd altered expression of this gene have been implicated in several neurological, neoplastic, ａnd other types of diseases, including Alzheimer＇s disease, Down＇s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, ａnd type I diabetes.S100B是一组可溶性、相对低分子质量、高酸性蛋白，属神经胶质细胞特异性蛋白，亦可存在于神经纤维中。在研究肠神经系统的形态特征及结构特征中，S100B有良好的表达功能。S100B蛋白其生理作用尚不清楚，可能与细胞内钙离子媒介的调节作用有关。S100B蛋白可存在于神经鞘瘤，成软骨细胞瘤、软骨肉瘤、骨肉瘤、神经胶质瘤、郎格罕斯细胞瘤、一些癌肿和黑素细胞肿瘤等。在免疫组化中，除了恶性黑素瘤皮损，S100B蛋白还在良性黑素细胞痣中增加，如：蓝痣、普通后天痣、雀斑样痣、Spitz痣、气球状细胞痣、色素性梭形细胞痣和发育不良痣中表达。还有报道S100B蛋白的染色强度与肿瘤细胞的黑素含量呈负相关。结缔组织增生性的或亲神经的黑素瘤不易染色。

（1mg/1mlS100B蛋白抗体Anti-S100B/S100 beta，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－S100B蛋白抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, bov, Rb, chk
产品类型：一抗
研究领域：肿瘤细胞生物免疫学神经生物学信号转导细胞周期蛋白
蛋白分子量：predicted molecular weight: 10kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from hu S100B/S100 beta
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

上海田源专业销售抗体产品，以下是在销售的部分抗体目录：

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Anti-HLA G（C-terminal）人类白细胞抗原G抗体（C端）
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Anti-CD71/TFR/Transferrin receptor转铁蛋白受体抗体
Anti-GAPDH（3E12）-Loading Control3-磷酸甘油醛脱氢酶单克隆抗体（内参抗体）
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Anti-14-3-3 family protein苹果14-3-3蛋白抗体（植物）
Anti-GLI1/Zfp5脑胶质瘤相关蛋白抗体（锌指蛋白5）
Anti-Involucrin囊包蛋白/内披蛋白抗体
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