产品展示
腺苷三磷酸结合盒转运体A1抗体,Anti-ABCA1/ABC1,一抗
点击次数:190发布时间:2012/6/15 12:35:29
更新日期:2013/5/6 17:00:55
所 在 地:其它
产品型号:
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详细内容
--产品介绍:The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Widely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.Similarity : Belongs to the ABC transporter superfamily. ABCA family.Contains 2 ABC transporter domains.Subunit : Interacts with MEGF10. ABCA1是一种调节细胞内胆固醇流出的膜蛋白,其功能障碍将导致巨噬细胞内沉积大量的胆固醇而成为泡沫细胞,继而浸润血管壁,促进动脉粥样硬化的发生、发展。
(1mg/1ml腺苷三磷酸结合盒转运体A1抗体Anti-ABCA1/ABC1,的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗)
--腺苷三磷酸结合盒转运体A1抗体的参数标准:
浓度:1mg/1ml
交叉反应:hu, mo, rat, hrs, dog
产品类型:一抗
研究领域:免疫学信号转导转录调节因子转运蛋白
蛋白分子量:predicted molecular weight: 254kDa
性状:Lyophilized or Liquid
免疫原:KLH conjugated synthetic peptide derived from human ABCA1
亚型:polyclonal
纯化方法:affinity purified by Protein A
储存液:0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用:WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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