第八因子抗体Anti-Factor VIII的产品详细说明：

－－产品介绍：Factor VIII, along with calcium ａnd phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Interacts with VWF. VWF binding is essential for the stabilization of F8 in circulation. Secreted protein; extracellular space. Domain F5/8 type C 2 is responsible for phospholipid-binding ａnd essential for factor VIII activity. Defects in F8 are the cause of hemophilia A （HEMA）. Belongs to the multicopper oxidase family.Subcellular Location : Secreted, extracellular space.Similarity : Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains.第VIII因子抗体用于血管源性良性和恶性肿瘤的诊断，也用于遗传性血友病的研究。在正常动脉、静脉、毛细血管及心脏内细胞的血管内皮细胞上阳性表达。第Ⅷ因子相关抗原抗体在巨核细胞及血小板上也有表达。第Ⅷ因子相关抗原:是一种糖蛋白，广泛存在于血管上皮、肝脏、脾窦上皮、及淋巴内皮细胞，是血管内皮细胞及其内源性良恶性肿瘤的特异性标记。主要用于血管原性良恶性肿瘤和血管肉瘤的诊断。少数副睾、子宫和输卵管的腺癌样瘤也有表达.

（1mg/1ml第八因子抗体Anti-Factor VIII，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－第八因子抗体的参数标准：
浓度：1mg/1ml
交叉反应：Rb, pig, dog, cow, hu, mo, rat
产品类型：一抗
研究领域：肿瘤心血管细胞生物信号转导细胞表面分子细胞类型标志物血管内皮细胞肿瘤细胞生物标志物
蛋白分子量：predicted molecular weight: 200/259kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from Rabbit Factor VIII
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

上海田源专业销售第八因子抗体抗体产品，详细抗体目录请访问：http://www.app17.com/c68810/products/t87312.html