维生素D3受体抗体Anti-Vitamin D Receptor/VDR的产品详细说明：

－－产品介绍：Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.Similarity : Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.Subunit : Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 ａnd NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts （in a ligand-dependent manner） with BAZ1B/WSTF.

（1mg/1ml维生素D3受体抗体Anti-Vitamin D Receptor/VDR，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－维生素D3受体抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, hrs, cow, pigm chk, Rb
产品类型：一抗
研究领域：细胞生物免疫学染色质和核信号
蛋白分子量：predicted molecular weight: 47kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human Vitamin D Receptor
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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