ABI1/SSH3BP1蛋白抗体Anti-ABI1的产品详细说明：

－－产品介绍：May act in negative regulation of cell growth ａnd transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 ａnd isoform 4 suppress the transforming activity of Abelson murine leukemia virus（v-Abl） after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization ａnd EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 ａnd SOS1 exhibits Rac specific guanine nucleotide exchange factor （GEF） activity ａnd ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA （By similarity）. Recruits WASF1 to lamellipodia ａnd there seems to regulate WASF1 protein level.Subcellular Location : Cytoplasm （By similarity）. Nucleus （By similarity）. Cell projection, lamellipodium （By similarity）. Cell projection, filopodium （By similarity）. Cell projection, growth cone （By similarity）. Cell junction, synapse, synaptosome （By similarity）. Cytoplasm, cytoskeleton （By similarity）. Note=Localized to protruding lamellipodia ａnd filopodia tips. Also localized to neuronal growth cones ａnd synaptosomes （By similarity）.Tissue Specificity : Widely expressed, with highest expression in brain.Similarity : Belongs to the ABI family. Contains 1 SH3 domain. Contains 1 t-SNARE coiled-coil homology domain.Subunit : Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, ａnd through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A ａnd SNAP25. Part of a complex consisting of ABI1, EPS8 ａnd SOS1 （By similarity）. Interacts with SOS1, SOS2, GRB2, SPTA1 ａnd the first SH3 domain of NCK1. Isoform 6 does not interact with NCK1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 ａnd WASF2/WAVE2.

（1mg/1mlABI1/SSH3BP1蛋白抗体Anti-ABI1，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－ABI1/SSH3BP1蛋白抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, rat, mo
产品类型：一抗
研究领域：免疫学信号转导转录调节因子
蛋白分子量：predicted molecular weight: 56kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human ABI1
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

上海田源专业销售ABI1/SSH3BP1蛋白抗体抗体产品，详细抗体目录请访问：http://www.app17.com/c68810/products/t87312.html