产品展示
穿膜蛋白DLK1抗体(C端),Anti-DLK1/Delta/DLL1 (C-terminus),一抗
点击次数:106发布时间:2012/6/17 13:19:07
更新日期:2013/5/6 17:19:33
所 在 地:其它
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详细内容
--产品介绍:This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010].Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary and, to a lesser degree, in adult kidney, muscle, thymus and heart.Similarity : Contains 6 EGF-like domains.Subunit : Monomer.穿膜蛋白DLK1又称肝癌相关基因,是表皮生长因子(EGF)家族的成员,其结构特征为蛋白的细胞外区域拥有在结构及氨基酸序列上与表皮生长因子高度同源的重复结构.DLK1可以抑制脂肪前体细胞向脂肪细胞分化,在正常神经内分泌细胞及其肿瘤细胞中表达, DLK1在神经内分泌轴中起着调控细胞生长分化的作用,同时DLK1在胚胎肝、造血干细胞及早期肌肉组织中均有表达。
(1mg/1ml穿膜蛋白DLK1抗体(C端)Anti-DLK1/Delta/DLL1 (C-terminus),的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗)
--穿膜蛋白DLK1抗体(C端)的参数标准:
浓度:1mg/1ml
交叉反应:hu, mo, rat, Rb, shp
产品类型:一抗
研究领域:肿瘤细胞生物免疫学神经生物学信号转导干细胞结合蛋白
蛋白分子量:predicted molecular weight: 42kDa
性状:Lyophilized or Liquid
免疫原:KLH conjugated synthetic peptide derived from hu DLK1/Delta/DLL1 (C-terminus)
亚型:polyclonal
纯化方法:affinity purified by Protein A
储存液:Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用:WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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