乙酰化组蛋白H4（K16）抗体Anti-Acetyl-Histone H4（K16）的产品详细说明：

－－产品介绍：Core component of nucleosome. Nucleosomes wrap ａnd compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication ａnd chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, ａnd nucleosome remodeling.Acetylation at Lys-6 （H4K5ac）, Lys-9 （H4K8ac）, Lys-13 （H4K12ac） ａnd Lys-17 （H4K16ac） occurs in coding regions of the genome but not in heterochromatin.Citrullination at Arg-4 （H4R3ci） by PADI4 impairs methylation.Monomethylation ａnd asymmetric dimethylation at Arg-4 （H4R3me1 ａnd H4R3me2a, respectively） by PRMT1 favors acetylation at Lys-9 （H4K8ac） ａnd Lys-13 （H4K12ac）. Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 （H4R3me2s） by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.Subcellular Location : Nucleus. Chromosome.

（1mg/1ml乙酰化组蛋白H4（K16）抗体Anti-Acetyl-Histone H4（K16），的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－乙酰化组蛋白H4（K16）抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, Rb, cow, hrs, dog, pig
产品类型：一抗乙酰化抗体
研究领域：细胞生物免疫学表观遗传学
蛋白分子量：predicted molecular weight: 12kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human Acetyl-Histone H4（K16）
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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