凝血因子7抗体Anti-Factor VII的产品详细说明：

－－产品介绍：Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor ａnd calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor ａnd calcium.Subcellular Location : Plasma.Involvement in diseaseDefects in F7 are the cause of factor VII deficiency （FA7D） . FA7D is a rare hereditary hemorrhagic disease. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages （epistaxis, menorrhagia） or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level.凝血因子7是肝脏合成的一种维生素K依赖性的单链糖蛋白,由4 0 6个氨基酸残基组成,分子量约45kD。凝血因子Ⅶ的半衰期*短（4～6h），血浆含量较低（0.5～2mg/L），故可作为肝病患者蛋白质合成功能减退的早期诊断指标。在慢性肝病患者通过肝活检组织原位杂交的方法检测到凝血因子Ⅶ的表达与肝纤维化的分级呈负相关，可作为预测纤维化程度的指标。凝血因子Ⅶ活性还与预后有着密切的联系，经研究认为：凝血因子Ⅶ活性<34%的肝硬化患者93%在随访10月内死亡，故认为它是肝硬化患者预后好坏的早期预测指标，可更好识别肝移植候选人。肝硬化患者凝血因子Ⅶ活性可明显下降，凝血因子Ⅶ缺乏可导致血小板活性的改变，结合血小板计数减少使出血时间延长，因此对有创诊断与治疗的肝硬化患者，还应该用凝血因子Ⅶ活性进行出血危险度的评估，而不能仅看血小板计数。除诊断之外，重组凝血因子Ⅶ可以地纠正肝病患者凝血异常，有利于有创性检查的进行。

（1mg/1ml凝血因子7抗体Anti-Factor VII，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－凝血因子7抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo
产品类型：一抗
研究领域：心血管细胞生物免疫学
蛋白分子量：predicted molecular weight: 28/45kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from hu Factor VII
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

上海田源专业销售凝血因子7抗体抗体产品，详细抗体目录请访问：http://www.app17.com/c68810/products/t87312.html