产品展示
磷酸化整合素β4抗体,Anti-phospho-ITGB4(Tyr1530),一抗磷酸化抗体
点击次数:163发布时间:2012/6/17 20:33:53
更新日期:2013/5/6 17:20:12
所 在 地:其它
产品型号:
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详细内容
--产品介绍:Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.Tissue Specificity : Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.Involvement in diseaseDefects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
(1mg/1ml磷酸化整合素β4抗体Anti-phospho-ITGB4(Tyr1530),的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗)
--磷酸化整合素β4抗体的参数标准:
浓度:1mg/1ml
交叉反应:hu
产品类型:一抗磷酸化抗体
研究领域:细胞生物免疫学信号转导细胞凋亡
蛋白分子量:predicted molecular weight: 197kDa
性状:Lyophilized or Liquid
免疫原:KLH conjugated synthetic peptide derived from hu phospho-ITGB4(Tyr1530)
亚型:polyclonal
纯化方法:affinity purified by Protein A
储存液:Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用:WB=1:100-500IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1:20-100IF=1:50-200 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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