磷酸化肾上腺素能受体β2抗体Anti-phospho-ADRB2（Ser346）的产品详细说明：

－－产品介绍：Beta 2 Adrenergic Receptor is a member of the G protein coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L type calcium channel Ca（V）1.2. This receptor channel complex also contains a G protein, an adenylyl cyclase, cAMP dependent kinase, ａnd the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific ａnd rapid signaling by this G protein coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity ａnd type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, ａnd vessel.Subcellular Location : Cell membrane; Multi-pass membrane protein.Similarity : Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.Subunit : Binds SLC9A3R1 ａnd GPRASP1. Interacts with ARRB1 ａnd ARRB2. Interacts with SRC, USP20 ａnd USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination.

（1mg/1ml磷酸化肾上腺素能受体β2抗体Anti-phospho-ADRB2（Ser346），的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－磷酸化肾上腺素能受体β2抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, dog, hrs, shp
产品类型：一抗磷酸化抗体
研究领域：神经生物学细胞膜受体内分泌病
蛋白分子量：predicted molecular weight: 46kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated Synthesised phosphopeptide derived from human ADRB2 around the phosphorylation site of Ser346
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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