激活素A受体1B抗体Anti-ACVR1B/ALK4的产品详细说明：

－－产品介绍：[FUNCTION]Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 （ACVR2A or ACVR2B）. Transduces the activin signal from the cell surface to the cytoplasm ａnd is thus regulating a many physiological ａnd pathological processes including neuronal differentiation ａnd neuronal survival, hair follicle development ａnd cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression ａnd carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors （ACVR2A and/or ACVR2B） act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane ａnd activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates ａnd activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds ａnd phosphorylates the SMAD proteins SMAD2 ａnd SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor ａnd subsequent phosphorylation, SMAD2 ａnd SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 ａnd SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.Subcellular Location : Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, ａnd liver.Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Subunit : Forms an activin receptor complex with activin receptor type-2 （ACVR2A or ACVR2B）. Interacts with TDP2 （By similarity）.

（1mg/1ml激活素A受体1B抗体Anti-ACVR1B/ALK4，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－激活素A受体1B抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, cow, hrs, pig, hrs, dog, Rb
产品类型：一抗
研究领域：免疫学信号转导干细胞激酶和磷酸酶结合蛋白
蛋白分子量：predicted molecular weight: 53kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human ACVR1B
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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