多聚免疫球蛋白受体抗体Anti-PIGR的产品详细说明：

－－产品介绍：PIGR is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy ａnd several SNPs in this gene.多聚免疫球蛋白受体（pIgR）属Ⅰ型跨膜糖蛋白，可与多聚免疫球蛋白A和多聚免疫球蛋白M特异性结合，通过穿胞转运，将它们从上皮细胞基底侧膜转运到顶膜，并*终分泌到外分泌液中去. 在此过程中，多聚免疫球蛋白受体的细胞外段被水解，释放出与多聚免疫球蛋白A或多聚免疫球蛋白M相结合的细胞外段（又称为分泌成分）. 分泌成分是sIgA分子的重要组成部分，直接参与sIgA的粘膜防御功能，而且在被动粘膜免疫中也有重要作用. 多聚免疫球蛋白受体通过介导细胞内多聚免疫球蛋白的转运，可以在粘膜的腔面阻止病原体粘附，在上皮细胞内中和病毒，也可以将固有层内的抗原分泌出去.

（1mg/1ml多聚免疫球蛋白受体抗体Anti-PIGR，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－多聚免疫球蛋白受体抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu
产品类型：一抗
研究领域：免疫学
蛋白分子量：predicted molecular weight: 83kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human PIGR
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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