钙粘蛋白1抗体Anti-E-cadherin/CD324的产品详细说明：

－－产品介绍：Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic mannerin connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanismsregulating cell-cell adhesions, mobility ａnd proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. [FUNCTION] E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 ａnd C83 production. [SUBUNIT] Homodimer; disulfide-linked. Interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions （CAJs）. Interacts with AJAP1, CTNND1 ａnd DLG7. [SUBCELLULAR LOCATION] Cell junction. Cell membrane; Single-pass type I membrane protein.Subcellular Location : Cell junction. Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Non-neural epithelial tissues.Similarity : Contains 5 cadherin domains.Subunit : Homodimer.Involvement in diseaseDefects in CDH1 are the cause of hereditary diffuse gastric cancer （HDGC） . An autosomal dominant cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, ａnd can extend through the stomach wall to nearby lymph nodes ａnd organs. It also can metastasize to other parts of the body. Note=Heterozygous germline mutations CDH1 are responsible for familial cases of diffuse gastric cancer. Somatic mutations in the has also been found in patients with sporadic diffuse gastric cancer ａnd lobular breast cancer.

（1mg/1ml钙粘蛋白1抗体Anti-E-cadherin/CD324，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－钙粘蛋白1抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, rat, mo
产品类型：一抗
研究领域：心血管免疫学神经生物学通道蛋白
蛋白分子量：predicted molecular weight: 80kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human E-cadherin C-terminus
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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