维甲酸相关孤儿受体α抗体Anti-ROR1/ROR alpha的产品详细说明：

－－产品介绍：NR1F1; Retinoid related orphan receptor alpha （ROR alpha） is a NR1 Thyroid Hormone Like Receptor. ROR alpha has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons ａnd results in the "staggerer" phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis ａnd rheumatoid arthritis. Within the ROR alpha group there are ROR alpha 1, 2, 3, ａnd 4. These isotypes have been shown to differ in only their amino terminus, ａnd their spatiotemporal expression appears to be under isoform specific regulation. ROR alpha isoforms have the same DNA binding domain but display different DNA binding specificities. ROR alpha 1 binds to ａnd constitutively activates transcription from a large subset of ROR elements, while ROR alpha 2 recognizes ROR elements with strict specificity ａnd displays weaker transcriptional activity. The structure of the ligand binding domain （LBD） of ROR alpha ａnd a potential natural ligand have been elucidated. ROR alpha expression has been documented in human adipose, brain, breast, heart, liver, lung, muscle, ovary, PBLs, prostate, small intestine, spleen ａnd testis. Research has shown that these proteins are key factors in the regulation of many physiological processes such as cell growth ａnd differentiation. ROR alpha is also critical for proper cerebellar development, modulation of gene expression in response to hypoxic stress, ａnd migratory capacities of cancer cells.Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Expressed strongly in human heart, lung ａnd kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal ａnd adult CNS ａnd in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.Contains 1 FZ （frizzled） domain.Contains 1 Ig-like C2-type （immunoglobulin-like） domain.Contains 1 kringle domain.Contains 1 protein kinase domain.

（1mg/1ml维甲酸相关孤儿受体α抗体Anti-ROR1/ROR alpha，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－维甲酸相关孤儿受体α抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, pig, cow, dog, hrs, Rb
产品类型：一抗
研究领域：肿瘤细胞生物染色质和核信号神经生物学细胞周期蛋白细胞分化
蛋白分子量：predicted molecular weight: 100kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human ROR1/ROR alpha corresponding to amino acids 365-406.
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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