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上海现货乳腺癌细胞分化因子P45抗体 Heregulinβ,Anti-NRG1/HRG beta 1,一抗
点击次数:188发布时间:2012/6/18 14:20:53
更新日期:2013/5/6 17:24:36
所 在 地:其它
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详细内容
--产品介绍:HRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.HRG1-? contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-? biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF).Subcellular Location : Pro-neuregulin-1, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Neuregulin-1: Secreted. Isoform 8: Nucleus. Isoform 9: Secreted. Isoform 10: Membrane; Single-pass type I membrane protein.Tissue Specificity : Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.Similarity : Belongs to the neuregulin family.Contains 1 EGF-like domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Subunit : The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity). Interacts with ERBB3 and ERBB4.神经胶质生长因子
(1mg/1ml乳腺癌细胞分化因子P45抗体 HeregulinβAnti-NRG1/HRG beta 1,的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗)
--乳腺癌细胞分化因子P45抗体 Heregulinβ的参数标准:
浓度:1mg/1ml
交叉反应:hu, mo, rat, Rb
产品类型:一抗
研究领域:肿瘤神经生物学信号转导
蛋白分子量:predicted molecular weight: 70kDa
性状:Lyophilized or Liquid
免疫原:KLH conjugated synthetic peptide derived from human NRG1
亚型:polyclonal
纯化方法:affinity purified by Protein A
储存液:Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用:WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1:100-500IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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