CD2结合蛋白3抗体Anti-SH3KBP1/CD2BP3的产品详细说明：

－－产品介绍：SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region ａnd a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation ａnd degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis ａnd lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR ａnd MET/hepatocyte growth factor receptor, through a association with CBL ａnd endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.

（1mg/1mlCD2结合蛋白3抗体Anti-SH3KBP1/CD2BP3，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－CD2结合蛋白3抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat
产品类型：一抗
研究领域：肿瘤信号转导
蛋白分子量：predicted molecular weight: 73kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human SH3KBP1/CD2BP3
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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