心肌兰尼碱受体抗体（脑肌兰尼碱受体）Anti-Ryanodine Receptor/HBRR/RyR的产品详细说明：

－－产品介绍：The Ryanodine Receptor （RyR） is the channel responsible for calcium release from muscle cell Sarcoplasmic Reticulum （SR） ａnd also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer ａnd is predicted to have a short cytoplasmic C-terminus ａnd 4-10 transmembrane domains. The remainder of the protein, termed the "foot" region, is located in the cytoplasm between the transverse tubule ａnd the SR. Mammalian RyR isoforms are the product of three different genes: RyR-1 is expressed predominantly in skeletal muscle ａnd areas of the brain; RyR-2 is expressed predominantly in heart muscle but also found in the stomach, endothelial cells ａnd diffuse areas of the brain; ａnd RyR-3 is found in smooth muscle ａnd the brain （striatum, thalamus ａnd hippocampus）. In non-mammalian vertebrates, the RyR isoforms are termed alpha, beta ａnd cardiac which correlate loosely to the mammalian RyR-1, RyR-3 ａnd RyR-2 isoforms respectively.Subcellular Location : Sarcoplasmic reticulum membrane; Multi-pass membrane protein （Probable）. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.Tissue Specificity : Brain, skeletal muscle, placenta ａnd possibly liver ａnd kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus ａnd amygdala, with lower levels in the corpus callosum, substantia nigra ａnd thalamus.Similarity : Belongs to the ryanodine receptor （TC 1.A.3.1） family. RYR3 subfamily.Contains 3 B30.2/SPRY domains.Contains 5 MIR domains.Subunit : Homotetramer. Heterotetramer with RYR2. Interacts with CALM. Interacts with FKBP1A.Defects in the RYR2 gene are the cause of several heart diseases: 1） familial arrhythmogenic right ventricular dysplasia 2 （ARVD2）, also known as arrhythmogenic right ventricular cardiomyopathy 2 （ARVC2）, 2） an autosomal dominant form of stress-induced polymorphic ventricular tachycardia （VTSIP）, also known as catecholaminergic polymorphic ventricular tachycardia （CPVT） ａnd 3） familial polymorphic ventricular tachycardia （FPVT）. Ryanodine Receptor 2 contains several phosphorylatable sites. Specifically, Ser-2030 ａnd Ser-2809 （or at Ser-2808 depending on the species） can be phosphoryated by protein kinase A （PKA） ａnd Ser-2815 （or at Ser-2814 depending on the species） can be phosphorylated by CaMKII （Ca2+/calmodulin-dependent protein kinase II）.

（1mg/1ml心肌兰尼碱受体抗体（脑肌兰尼碱受体）Anti-Ryanodine Receptor/HBRR/RyR，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－心肌兰尼碱受体抗体（脑肌兰尼碱受体）的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, dog, Rb, cow, pig
产品类型：一抗
研究领域：肿瘤心血管通道蛋白细胞膜受体
蛋白分子量：predicted molecular weight: 565kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from hu Ryanodine Receptor/HBRR/RyR
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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